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Verfasst von:Dyckhoff, Gerhard [VerfasserIn]   i
 Warta, Rolf [VerfasserIn]   i
 Herold-Mende, Christel [VerfasserIn]   i
 Rudolph, Elisabeth [VerfasserIn]   i
 Plinkert, Peter K. [VerfasserIn]   i
 Ramroth, Heribert [VerfasserIn]   i
Titel:Could primary chemoradiotherapy in T2 glottic cancers yield results comparable to primary radiotherapy in T1?
Titelzusatz:considerations from 531 German early stage patients
Verf.angabe:Gerhard Dyckhoff, Rolf Warta, Christel Herold-Mende, Elisabeth Rudolph, Peter K. Plinkert and Heribert Ramroth
E-Jahr:2021
Jahr:31 March 2021
Umfang:20 S.
Teil:volume:13
 year:2021
 number:7
 elocationid:1601
 pages:1-20
 extent:20
Fussnoten:Gesehen am 16.06.2021
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2021
Band/Heft Quelle:13(2021), 7, Artikel-ID 1601, Seite 1-20
ISSN Quelle:2072-6694
Abstract:T1 glottic cancer is a highly treatable disease with local control (LC) rates over 90% by either primary radiotherapy (pRT) or transoral laser microsurgery (TLM). LC of T2 glottic cancers is 15 percent points poorer on average. However, salvage after pRT entails more than 50% total laryngectomy. Therefore, there is a need for enhanced LC. Altered fractionation regimens improved LC in T1 but not in T2. For this reason, for T2, alternative strategies must be considered. In a large observational cohort study including 531 early-stage laryngeal cancers, a small number of patients were treated with primary chemoradiotherapy (pCRT). In multivariable analysis, factors associated with significantly poorer outcomes included age, comorbidities, supraglottic localization, and T category. While there was a significant difference between pRT and surgery (HR 1.79; 95%-CI: 1.15-2.79), there was none between pCRT and surgery (HR 0.70; 95%-CI: 0.33-1.51). There is evidence from the literature that pCRT in early glottic cancers could yield results that surpass the limits so far experienced in radiotherapy alone with acceptable toxicity. Thus, prospective randomized studies with larger numbers of patients are warranted.
DOI:doi:10.3390/cancers13071601
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/cancers13071601
 Volltext: https://www.mdpi.com/2072-6694/13/7/1601
 DOI: https://doi.org/10.3390/cancers13071601
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:laryngeal cancer
 organ preservation
 radiochemotherapy
 radiotherapy
 survival
 transoral laser microsurgery
K10plus-PPN:1757740163
Verknüpfungen:→ Zeitschrift

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