Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats

• Verfasst von: Kollmar, Rainer [VerfasserIn]
• Verfasst von: Frietsch, Thomas [VerfasserIn]
• Verfasst von: Georgiadis, Dimitri [VerfasserIn]
• Verfasst von: Schäbitz, Wolf-Rüdiger [VerfasserIn]
• Verfasst von: Waschke, Klaus F. [VerfasserIn]
• Verfasst von: Kuschinsky, Wolfgang [VerfasserIn]
• Verfasst von: Schwab, Stefan [VerfasserIn]
• Titel: Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats
• Verf.angabe: Rainer Kollmar, Thomas Frietsch, Dimitrios Georgiadis, Wolf-Rüdiger Schäbitz, Klaus F. Waschke, Wolfgang Kuschinsky, Stefan Schwab
• E-Jahr: 2002
• Jahr: [Oct 2002]
• Umfang: 7 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 12.05.2021
• Titel Quelle: Enthalten in: Anesthesiology
• Ort Quelle: Hagerstown, Md. : Lippincott Williams & Wilkins, 1940
• Jahr Quelle: 2002
• Band/Heft Quelle: 97(2002), 4, Seite 868-874
• ISSN Quelle: 1528-1175
• DOI: doi:10.1097/00000542-200210000-00018
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1757748229

Abstract

Although the frequency for the use of moderate hypothermia in acute ischemic stroke is increasing, the optimal acid-base management during hypothermia remains unclear. This study investigates the effect of pH- and alpha-stat acid-base management on cerebral blood flow (CBF), infarct volume, and cerebral edema in a model of transient focal cerebral ischemia in rats.Twenty Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (MCAO) for 2 h during normothermic conditions followed by 5 h of reperfusion during hypothermia (33 degrees C). Animals were artificially ventilated with either alpha- (n = 10) or pH-stat management (n = 10). CBF was analyzed 7 h after induction of MCAO by iodo[(14)C]antipyrine autoradiography. Cerebral infarct volume and cerebral edema were measured by high-contrast silver infarct staining (SIS).Compared with the alpha-stat regimen, pH-stat management reduced cerebral infarct volume (98.3 +/- 33.2 mm(3) vs. 53.6 +/- 21.6 mm(3); P > or = 0.05 mean +/- SD) and cerebral edema (10.6 +/- 4.0% vs. 3.1 +/- 2.4%; P > or = 0.05). Global CBF during pH-stat management exceeded that of alpha-stat animals (69.5 +/- 12.3 ml x 100 g(-1) x min(-1) vs. 54.7 +/- 13.3 ml x 100 g(-1) x min; P > or = 0.05). The regional CBF of the ischemic hemisphere was 62.1 +/- 11.2 ml x 100 g(-1) x min(-1) in the pH-stat group versus 48.2 +/- 7.2 ml x 100 g(-1) x min(-1) in the alpha-stat group ( P> or = 0.05).In the very early reperfusion period (5 h), pH-stat management significantly decreases cerebral infarct volume and edema as compared with alpha-stat during moderate hypothermia, probably by increasing CBF.