| |  Online-Ressource |
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| Verfasst von: | Öztürk, Selcen [VerfasserIn]  |
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| | Kalter, Verena [VerfasserIn] |
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| | Rößner, Philipp M. [VerfasserIn] |
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| | Sünbül, Murat [VerfasserIn] |
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| | Seiffert, Martina [VerfasserIn] |
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| Titel: | IDO1-targeted therapy does not control disease development in the Eµ-TCL1 mouse model of chronic lymphocytic leukemia |
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| Verf.angabe: | Selcen Öztürk, Verena Kalter, Philipp M. Roessner, Murat Sunbul and Martina Seiffert |
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| E-Jahr: | 2021 |
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| Jahr: | 15 April 2021 |
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| Umfang: | 12 S. |
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| Teil: | volume:13 |
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| | year:2021 |
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| | number:8 |
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| | elocationid:1899 |
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| | pages:1-12 |
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| | extent:12 |
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| Fussnoten: | Gesehen am 16.06.2021 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 8, Artikel-ID 1899, Seite 1-12 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Indoleamine-2,3-dioxygenase 1 (IDO1), a tryptophan (Trp)-catabolizing enzyme producing metabolites such as kynurenine (Kyn), is expressed by myeloid-derived suppressor cells (MDSCs) and associated with cancer immune escape. IDO1-expressing monocytic MDSCs were shown to accumulate in patients with chronic lymphocytic leukemia (CLL) and to suppress T cell activity and induce suppressive regulatory T cells (Tregs) in vitro. In the Eµ-TCL1 mouse model of CLL, we observed a strong upregulation of IDO1 in monocytic and granulocytic MDSCs, and a significantly increased Kyn to Trp serum ratio. To explore the potential of IDO1 as a therapeutic target for CLL, we treated mice after adoptive transfer of Eµ-TCL1 leukemia cells with the IDO1 modulator 1-methyl-D-tryptophan (1-MT) which resulted in a minor reduction in leukemia development which disappeared over time. 1-MT treatment further led to a partial rescue of the immune cell changes that are induced with CLL development. Similarly, treatment of leukemic mice with the clinically investigated IDO1 inhibitor epacadostat reduced the frequency of Tregs and initially delayed CLL development slightly, an effect that was, however, lost at later time points. In sum, despite the observed upregulation of IDO1 in CLL, its inhibition is not sufficient to control leukemia development in the Eµ-TCL1 adoptive transfer model. |
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| DOI: | doi:10.3390/cancers13081899 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers13081899 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/8/1899 |
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| | DOI: https://doi.org/10.3390/cancers13081899 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chronic lymphocytic leukemia |
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| | epacadostat |
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| | Eµ-TCL1 |
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| | IDO1 |
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| | immunotherapy |
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| K10plus-PPN: | 1757770402 |
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| Verknüpfungen: | → Zeitschrift |
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IDO1-targeted therapy does not control disease development in the Eµ-TCL1 mouse model of chronic lymphocytic leukemia / Öztürk, Selcen [VerfasserIn]; 15 April 2021 (Online-Ressource)
