| |  Online-Ressource |
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| Verfasst von: | Westhauser, Fabian [VerfasserIn]  |
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| | Decker, Simon [VerfasserIn] |
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| | Nawaz, Qaisar [VerfasserIn] |
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| | Rehder, Felix [VerfasserIn] |
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| | Wilkesmann, Sebastian [VerfasserIn] |
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| | Moghaddam-Alvandi, Arash [VerfasserIn] |
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| | Kunisch, Elke [VerfasserIn] |
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| | Boccaccini, Aldo R. [VerfasserIn] |
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| Titel: | Impact of zinc- or copper-doped mesoporous bioactive glass nanoparticles on the osteogenic differentiation and matrix formation of mesenchymal stromal cells |
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| Verf.angabe: | Fabian Westhauser, Simon Decker, Qaisar Nawaz, Felix Rehder, Sebastian Wilkesmann, Arash Moghaddam, Elke Kunisch and Aldo R. Boccaccini |
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| E-Jahr: | 2021 |
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| Jahr: | 9 April 2021 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 01.02.2022 |
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| Titel Quelle: | Enthalten in: Materials |
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| Ort Quelle: | Basel : MDPI, 2008 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 14(2021), 8, Artikel-ID 1864, Seite 1-13 |
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| ISSN Quelle: | 1996-1944 |
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| Abstract: | Mesoporous bioactive glass nanoparticles (MBGNs) have gained relevance in bone tissue engineering, especially since they can be used as vectors for therapeutically active ions like zinc (Zn) or copper (Cu). In this study, the osteogenic properties of the ionic dissolution products (IDPs) of undoped MBGNs (composition in mol%: 70 SiO2, 30 CaO) and MBGNs doped with 5 mol% of either Zn (5Zn-MBGNs) or Cu (5Cu-MBGNs; compositions in mol%: 70 SiO2, 25 CaO, 5 ZnO/CuO) on human bone marrow-derived mesenchymal stromal cells were evaluated. Extracellular matrix (ECM) formation and calcification were assessed, as well as the IDPs’ influence on viability, cellular osteogenic differentiation and the expression of genes encoding for relevant members of the ECM. The IDPs of undoped MBGNs and 5Zn-MBGNs had a comparable influence on cell viability, while it was enhanced by IDPs of 5Cu-MBGNs compared to the other MBGNs. IDPs of 5Cu-MBGNs had slightly positive effects on ECM formation and calcification. 5Zn-MBGNs provided the most favorable pro-osteogenic properties since they increased not only cellular osteogenic differentiation and ECM-related gene expression but also ECM formation and calcification significantly. Future studies should analyze other relevant properties of MBGNs, such as their impact on angiogenesis. |
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| DOI: | doi:10.3390/ma14081864 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ma14081864 |
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| | Volltext: https://www.mdpi.com/1996-1944/14/8/1864 |
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| | DOI: https://doi.org/10.3390/ma14081864 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | copper |
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| | extracellular matrix |
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| | mesoporous bioactive glass nanoparticles |
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| | osteogenic differentiation |
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| | zinc |
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| K10plus-PPN: | 1757846115 |
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| Verknüpfungen: | → Zeitschrift |
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Impact of zinc- or copper-doped mesoporous bioactive glass nanoparticles on the osteogenic differentiation and matrix formation of mesenchymal stromal cells / Westhauser, Fabian [VerfasserIn]; 9 April 2021 (Online-Ressource)
