| |  Online-Ressource |
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| Verfasst von: | Schott, Melanie [VerfasserIn]  |
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| | Grosskinsky, Sonja [VerfasserIn] |
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| | Brenner, Christiane [VerfasserIn] |
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| | Kraiczy, Peter [VerfasserIn] |
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| | Wallich, Reinhard [VerfasserIn] |
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| Titel: | Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators |
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| Verf.angabe: | Melanie Schott, Sonja Grosskinsky, Christiane Brenner, Peter Kraiczy, and Reinhard Wallich |
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| E-Jahr: | 2010 |
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| Jahr: | 15 March 2010 |
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| Umfang: | 10 S. |
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| Teil: | volume:78 |
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| | year:2010 |
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| | number:5 |
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| | pages:2199-2208 |
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| | extent:10 |
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| Fussnoten: | Gesehen am 17.05.2021 |
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| Titel Quelle: | Enthalten in: Infection and immunity |
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| Ort Quelle: | Washington, DC : Soc., 1970 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 78(2010), 5, Seite 2199-2208 |
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| ISSN Quelle: | 1098-5522 |
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| Abstract: | In North America, tick-borne relapsing fever is caused by the species Borrelia hermsii, B. parkeri, and B. turicatae, which are transmitted to humans through the bite of the respective infected tick vectors. Here we describe the identification and functional characterization of a surface lipoprotein of B. parkeri, designated BpcA, that binds the human complement regulators factor H and factor H-related protein 1 and, simultaneously, the host protease plasminogen. In contrast, the homologous B. turicatae protein failed to bind human factor H and factor H-related protein 1 but retained its plasminogen binding capacity. Factor H bound to BpcA maintains its regulatory capacity to control C3b deposition and C3 convertase activity. Ectopic expression of BpcA in a serum-sensitive B. burgdorferi strain protects transformed cells from complement-mediated killing. Furthermore, bound plasminogen/plasmin endows B. parkeri and B. turicatae with the potential to degrade extracellular matrix components. These findings expand our understanding of the putative recent evolutionary separation of Borrelia parkeri and Borrelia turicatae, provide evidence that B. parkeri differs from B. turicatae in its ability to resist complement attack, and may help in understanding the pathological processes underlying tick-borne relapsing fever. |
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| DOI: | doi:10.1128/IAI.00089-10 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://dx.doi.org/10.1128/IAI.00089-10 |
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| | Volltext: https://iai.asm.org/content/78/5/2199 |
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| | DOI: https://doi.org/10.1128/IAI.00089-10 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Amino Acid Sequence |
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| | Bacterial Proteins |
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| | Blood Bactericidal Activity |
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| | Blood Proteins |
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| | Borrelia |
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| | Complement Factor H |
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| | DNA, Bacterial |
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| | Humans |
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| | Molecular Sequence Data |
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| | North America |
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| | Plasminogen |
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| | Protein Binding |
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| | Sequence Alignment |
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| | Sequence Analysis, DNA |
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| K10plus-PPN: | 1757905340 |
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| Verknüpfungen: | → Zeitschrift |
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Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators / Schott, Melanie [VerfasserIn]; 15 March 2010 (Online-Ressource)
