B cell-regulated immune responses in tumor models and cancer patients

• Verfasst von: Fremd, Carlo [VerfasserIn]
• Verfasst von: Schütz, Florian [VerfasserIn]
• Verfasst von: Sohn, Christof [VerfasserIn]
• Verfasst von: Beckhove, Philipp [VerfasserIn]
• Verfasst von: Domschke, Christoph [VerfasserIn]
• Titel: B cell-regulated immune responses in tumor models and cancer patients
• Verf.angabe: Carlo Fremd, Florian Schuetz, Christof Sohn, Philipp Beckhove & Christoph Domschke
• E-Jahr: 2013
• Jahr: 01 Jul 2013
• Umfang: 10 S.
• Teil: volume:2
• Teil: year:2013
• Teil: number:7
• Teil: elocationid:e25443
• Teil: extent:10
• Fussnoten: Gesehen am 17.05.2021
• Titel Quelle: Enthalten in: OncoImmunology
• Ort Quelle: Abingdon : Taylor & Franics, 2012
• Jahr Quelle: 2013
• Band/Heft Quelle: 2(2013), 7, Artikel-ID e25443
• ISSN Quelle: 2162-402X
• DOI: doi:10.4161/onci.25443
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: antitumor immunity
• Sach-SW: B cells
• Sach-SW: regulatory B cells
• Sach-SW: T cells
• Sach-SW: Tregs
• Sach-SW: tumor-specific immune responses
• K10plus-PPN: 175790591X

Abstract

The essential role played by T cells in anticancer immunity is widely accepted. The immunosuppressive functions of regulatory T cells are central for tumor progression and have been endowed with a robust predictive value. Increasing evidence indicates that also B cells have a crucial part in the regulation of T-cell responses against tumors. Although experiments reporting the production of natural antitumor antibodies and the induction of cytotoxic immune responses have revealed a tumor-protective function for B cells, other findings suggest that B cells may also exert tumor-promoting functions, resulting in a controversial picture. Here, we review recent evidence on the interactions between B and T cells in murine models and cancer patients and their implications for cancer immunology.