| |  Online-Ressource |
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| Verfasst von: | Herz, Jasmin [VerfasserIn]  |
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| | Pardo, Julian [VerfasserIn] |
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| | Kashkar, Hamid [VerfasserIn] |
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| | Schramm, Michael [VerfasserIn] |
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| | Kuzmenkina, Elza [VerfasserIn] |
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| | Bos, Erik [VerfasserIn] |
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| | Wiegmann, Katja [VerfasserIn] |
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| | Wallich, Reinhard [VerfasserIn] |
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| | Peters, Peter J. [VerfasserIn] |
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| | Herzig, Stefan [VerfasserIn] |
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| | Schmelzer, Elmon [VerfasserIn] |
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| | Krönke, Martin [VerfasserIn] |
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| | Simon, Markus M. [VerfasserIn] |
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| | Utermöhlen, Olaf [VerfasserIn] |
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| Titel: | Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes |
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| Verf.angabe: | Jasmin Herz, Julian Pardo, Hamid Kashkar, Michael Schramm, Elza Kuzmenkina, Erik Bos, Katja Wiegmann, Reinhard Wallich, Peter J. Peters, Stefan Herzig, Elmon Schmelzer, Martin Krönke, Markus M. Simon & Olaf Utermöhlen |
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| E-Jahr: | 2009 |
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| Jahr: | 14 June 2009 |
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| Umfang: | 8 S. |
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| Teil: | volume:10 |
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| | year:2009 |
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| | number:7 |
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| | pages:761-768 |
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| | extent:8 |
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| Fussnoten: | Gesehen am 17.05.2021 |
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| Titel Quelle: | Enthalten in: Nature immunology |
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| Ort Quelle: | London : Springer Nature Limited, 2000 |
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| Jahr Quelle: | 2009 |
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| Band/Heft Quelle: | 10(2009), 7, Seite 761-768 |
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| ISSN Quelle: | 1529-2916 |
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| Abstract: | Granule-mediated cytotoxicity is the main effector mechanism of cytotoxic CD8+ T cells. We report that CD8+ T cells from acid sphingomyelinase (ASMase)-deficient (ASMase-KO) mice are defective in exocytosis of cytolytic effector molecules; this defect resulted in attenuated cytotoxic activity of ASMase-KO CD8+ T cells and delayed elimination of lymphocytic choriomeningitis virus from ASMase-KO mice. Cytolytic granules of ASMase-KO and wild-type CD8+ T cells were equally loaded with granzymes and perforin, and correctly directed to the immunological synapse. In wild-type CD8+ T cells, secretory granules underwent shrinkage by 82% after fusion with the plasma membrane. In ASMase-KO CD8+ T cells, the contraction of secretory granules was markedly impaired. Thus, ASMase is required for contraction of secretory granules and expulsion of cytotoxic effector molecules. |
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| DOI: | doi:10.1038/ni.1757 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/ni.1757 |
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| | Volltext: https://www.nature.com/articles/ni.1757 |
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| | DOI: https://doi.org/10.1038/ni.1757 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Arenaviridae Infections |
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| | CD8-Positive T-Lymphocytes |
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| | Chemokine CCL5 |
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| | Cytotoxicity, Immunologic |
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| | Female |
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| | Granzymes |
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| | Immunoblotting |
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| | Immunological Synapses |
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| | Lymphocytic choriomeningitis virus |
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| | Male |
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| | Mice |
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| | Mice, Knockout |
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| | Microscopy, Fluorescence |
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| | Perforin |
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| | Reverse Transcriptase Polymerase Chain Reaction |
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| | Secretory Vesicles |
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| | Sphingomyelin Phosphodiesterase |
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| | T-Lymphocytes |
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| | T-Lymphocytes, Cytotoxic |
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| K10plus-PPN: | 1757914919 |
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| Verknüpfungen: | → Zeitschrift |
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Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes / Herz, Jasmin [VerfasserIn]; 14 June 2009 (Online-Ressource)
