| |  Online-Ressource |
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| Verfasst von: | Zwicker, Felix [VerfasserIn]  |
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| | Hoefel, Sebastian [VerfasserIn] |
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| | Kirchner, Corinna [VerfasserIn] |
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| | Huber, Peter E. [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Schempp, Michael [VerfasserIn] |
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| Titel: | Hypofractionated radiotherapy with simultaneous-integrated boost after breast-conserving surgery compared to standard boost-applications using helical tomotherapy with TomoEdge |
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| Verf.angabe: | Felix Zwicker, Sebastian Hoefel, Corinna Kirchner, Peter E. Huber, Juergen Debus and Michael Schempp |
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| E-Jahr: | 2021 |
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| Jahr: | April 3, 2021 |
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| Umfang: | 12 S. |
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| Teil: | volume:41 |
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| | year:2021 |
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| | number:4 |
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| | pages:1909-1920 |
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| | extent:12 |
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| Fussnoten: | Gesehen am 17.05.2021 |
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| Titel Quelle: | Enthalten in: Anticancer research |
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| Ort Quelle: | Attiki, 2004 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 41(2021), 4, Seite 1909-1920 |
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| ISSN Quelle: | 1791-7530 |
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| Abstract: | Background/Aim: This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined. Patients and Methods: For 10 patients with left-sided breast cancer each four helical IMRT-plans with TomoEdge-technique were created: hypofractionated+SIB (H-SIB) (42.4/54.4 Gy, 16 fractions), normofractionated+SIB (N-SIB) (50.4/64.4 Gy, 28 fractions), hypofractionated+sequential-boost (H-SB) (42.4 Gy/16 fractions+16 Gy/8 fractions), normofractionated+ sequential-boost (N-SB) (50.4 Gy/28 fractions+16 Gy/8 fractions). Equivalent doses (EQD2) to organs-at-risk (OAR) and irradiated mammary-gland were analysed for different assumed α/β-values. Results: The mean EQD2 to OAR was significantly lower using hypofractionated radiation-techniques. H-SIB and H-SB were not significantly different. H-SIB and N-SIB conformed significantly better to the breast planning-target volume (PTV) and boost-volume (BV) than H-SB and N-SB. Regarding BV, mean EQD2 was significantly higher for all α/β-values investigated when using H-SIB and N-SIB. Regarding PTV, there were no clinically relevant differences. Conclusion: Relating to dosimetry, H-SIB is effective compared to standard-boost-techniques. |
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| DOI: | doi:10.21873/anticanres.14957 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.21873/anticanres.14957 |
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| | Volltext: https://ar.iiarjournals.org/content/41/4/1909 |
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| | DOI: https://doi.org/10.21873/anticanres.14957 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | breast cancer |
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| | helical tomotherapy |
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| | Hypofractionated radiotherapy |
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| | IMRT |
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| | SIB |
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| | simultaneous integrated boost |
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| | TomoEdge |
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| K10plus-PPN: | 1757941452 |
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| Verknüpfungen: | → Zeitschrift |
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Hypofractionated radiotherapy with simultaneous-integrated boost after breast-conserving surgery compared to standard boost-applications using helical tomotherapy with TomoEdge / Zwicker, Felix [VerfasserIn]; April 3, 2021 (Online-Ressource)
