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Verfasst von:Witzmann, Katharina [VerfasserIn]   i
 Raschke, Felix [VerfasserIn]   i
 Troost, Esther Gera Cornelia [VerfasserIn]   i
Titel:MR image changes of normal-appearing brain tissue after radiotherapy
Verf.angabe:Katharina Witzmann, Felix Raschke and Esther G.C. Troost
E-Jahr:2021
Jahr:29 March 2021
Umfang:27 S.
Teil:volume:13
 year:2021
 number:7
 elocationid:1573
 pages:1-27
 extent:27
Fussnoten:Gesehen am 17.05.2021
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2021
Band/Heft Quelle:13(2021), 7, Artikel-ID 1573, Seite 1-27
ISSN Quelle:2072-6694
Abstract:Radiotherapy is part of the standard treatment of most primary brain tumors. Large clinical target volumes and physical characteristics of photon beams inevitably lead to irradiation of surrounding normal brain tissue. This can cause radiation-induced brain injury. In particular, late brain injury, such as cognitive dysfunction, is often irreversible and progressive over time, resulting in a significant reduction in quality of life. Since 50% of patients have survival times greater than six months, radiation-induced side effects become more relevant and need to be balanced against radiation treatment given with curative intent. To develop adequate treatment and prevention strategies, the underlying cause of radiation-induced side-effects needs to be understood. This paper provides an overview of radiation-induced changes observed in normal-appearing brains measured with conventional and advanced MRI techniques and summarizes the current findings and conclusions. Brain atrophy was observed with anatomical MRI. Changes in tissue microstructure were seen on diffusion imaging. Vascular changes were examined with perfusion-weighted imaging and susceptibility-weighted imaging. MR spectroscopy revealed decreasing N-acetyl aspartate, indicating decreased neuronal health or neuronal loss. Based on these findings, multicenter prospective studies incorporating advanced MR techniques as well as neurocognitive function tests should be designed in order to gain more evidence on radiation-induced sequelae.
DOI:doi:10.3390/cancers13071573
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/cancers13071573
 Volltext: https://www.mdpi.com/2072-6694/13/7/1573
 DOI: https://doi.org/10.3390/cancers13071573
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:anatomical MRI
 atrophy
 diffusion
 functional MRI
 normal-appearing brain tissue
 perfusion
 radiation-induced brain injuries
 radiotherapy
 spectroscopy
K10plus-PPN:1757947493
Verknüpfungen:→ Zeitschrift

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