| |  Online-Ressource |
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| Verfasst von: | Liu, Mingzhu [VerfasserIn]  |
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| | Roth, Anna [VerfasserIn] |
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| | Yu, Min [VerfasserIn] |
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| | Morris, Robert [VerfasserIn] |
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| | Bersani, Francesca [VerfasserIn] |
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| | Rivera, Miguel N. [VerfasserIn] |
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| | Lu, Jun [VerfasserIn] |
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| | Shioda, Toshihiro [VerfasserIn] |
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| | Vasudevan, Shobha [VerfasserIn] |
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| | Ramaswamy, Sridhar [VerfasserIn] |
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| | Maheswaran, Shyamala [VerfasserIn] |
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| | Diederichs, Sven [VerfasserIn] |
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| | Haber, Daniel A. [VerfasserIn] |
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| Titel: | The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis |
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| Verf.angabe: | Mingzhu Liu, Anna Roth, Min Yu, Robert Morris, Francesca Bersani, Miguel N. Rivera, Jun Lu, Toshihiro Shioda, Shobha Vasudevan, Sridhar Ramaswamy, Shyamala Maheswaran, Sven Diederichs, and Daniel A. Haber |
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| E-Jahr: | 2013 |
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| Jahr: | December 1, 2013 |
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| Umfang: | 6 S. |
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| Teil: | volume:27 |
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| | year:2013 |
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| | pages:2543-2548 |
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| | extent:6 |
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| Fussnoten: | Gesehen am 18.05.2021 |
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| Titel Quelle: | Enthalten in: Genes & development |
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| Ort Quelle: | Stanford, Calif. : HighWire Press, 1987 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 27(2013), Seite 2543-2548 |
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| ISSN Quelle: | 1549-5477 |
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| Abstract: | Insulin-like growth factor 2 (IGF2), a developmentally regulated and maternally imprinted gene, is frequently overexpressed in pediatric cancers. Although loss of imprinting (LOI) at fetal promoters contributes to increased IGF2 in tumors, the magnitude of IGF2 expression suggests the involvement of additional regulatory mechanisms. A microRNA (miRNA) screen of primary Wilms' tumors identified specific overexpression of miR-483-5p, which is embedded within the IGF2 gene. Unexpectedly, the IGF2 mRNA itself is transcriptionally up-regulated by miR-483-5p. A nuclear pool of miR-483-5p binds directly to the 5′ untranslated region (UTR) of fetal IGF2 mRNA, enhancing the association of the RNA helicase DHX9 to the IGF2 transcript and promoting IGF2 transcription. Ectopic expression of miR-483-5p in IGF2-dependent sarcoma cells is correlated with increased tumorigenesis in vivo. Together, these observations suggest a functional positive feedback loop of an intronic miRNA on transcription of its host gene. |
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| DOI: | doi:10.1101/gad.224170.113 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1101/gad.224170.113 |
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| | Volltext: http://genesdev.cshlp.org/content/27/23/2543 |
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| | DOI: https://doi.org/10.1101/gad.224170.113 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | fetal promoters |
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| | IGF2 |
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| | nuclear miRNA |
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| | transcription |
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| K10plus-PPN: | 1758126760 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis / Liu, Mingzhu [VerfasserIn]; December 1, 2013 (Online-Ressource)
