Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Lenz, Christian [VerfasserIn]   i
 Frietsch, Thomas [VerfasserIn]   i
 Fütterer, Carsten Dietmar [VerfasserIn]   i
 Ackern, Klaus van [VerfasserIn]   i
 Kuschinsky, Wolfgang [VerfasserIn]   i
 Waschke, Klaus F. [VerfasserIn]   i
Titel:Influence of blood viscosity on blood flow in the forebrain but not hindbrain after carotid occlusion in rats
Verf.angabe:Christian Lenz, Thomas Frietsch, Carsten Fütterer, Klaus van Ackern, Wolfgang Kuschinsky, and Klaus F. Waschke
E-Jahr:2000
Jahr:[2000]
Umfang:9 S.
Fussnoten:Gesehen am 19.05.2021
Titel Quelle:Enthalten in: Journal of cerebral blood flow & metabolism
Ort Quelle:Thousands Oaks, Calif. : Sage, 1981
Jahr Quelle:2000
Band/Heft Quelle:20(2000), 6, Seite 947-955
ISSN Quelle:1559-7016
Abstract:That cerebral blood flow remains unchanged at an increased blood viscosity, as long as the vascular supply is not compromised, was tested. To induce a reduced blood supply of some parts of the brain and to keep the supply unchanged in others both carotid arteries were occluded in anesthetized, ventilated rats. By this procedure, blood supply to the rostral brain, but not to the brainstem and cerebellum, was compromised. Blood viscosity was increased by intravenous infusion of 20% polyvinylpyrrolidone (high viscosity group) or decreased by infusion of 5% albumin (low viscosity group). Cerebral blood flow was measured by the [14C]iodoantipyrine method in 50 complete coronal sections of the rostral brain and 22 complete coronal sections of the brainstem and cerebellum in each rat. In the high viscosity group, mean cerebral blood flow of the rostral brain was significantly lower (46 ± 7 mL/100 g−1 · min−1) than in the low viscosity group (82 ± 18 mL/100 g−1 · min−1). No differences could be observed in brainstem and cerebellum between both groups (162 ± 29 mL/100 g−1 · min−1 vs. 156 ± 18 mL/100 g−1 · min−1). Local analysis of cerebral blood flow in different brain structures of the coronal sections showed the same identical results; i.e., in 29 of the 31 brain structures analyzed in rostral brain, local cerebral blood flow was lower in the high viscosity group, whereas no differences could be observed in the 11 brain structures analyzed in the brainstem and cerebellum. It is concluded that under normal conditions cerebral blood flow can be maintained at an increased blood viscosity by a compensatory vasodilation. When the capacity for vasodilation is exhausted by occlusion of supplying arteries, an increased blood viscosity results in a decrease of cerebral blood flow.
DOI:doi:10.1097/00004647-200006000-00007
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/00004647-200006000-00007
 DOI: https://doi.org/10.1097/00004647-200006000-00007
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Animals
 Autoradiography
 Blood viscosity
 Cerebral circulation
 Collateral flow
 Rats
 Two vessel occlusion
K10plus-PPN:1758167475
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68739453   QR-Code
zum Seitenanfang