Relationship between local cerebral blood flow and metabolism during mild and moderate hypothermia in rats

• Verfasst von: Frietsch, Thomas [VerfasserIn]
• Verfasst von: Krafft, Peter [VerfasserIn]
• Verfasst von: Piepgras, Axel [VerfasserIn]
• Verfasst von: Lenz, Christian [VerfasserIn]
• Verfasst von: Kuschinsky, Wolfgang [VerfasserIn]
• Verfasst von: Waschke, Klaus F. [VerfasserIn]
• Titel: Relationship between local cerebral blood flow and metabolism during mild and moderate hypothermia in rats
• Verf.angabe: Thomas Frietsch, Peter Krafft, Axel Piepgras, Christian Lenz, Wolfgang Kuschinsky, Klaus F. Waschke
• E-Jahr: 2000
• Jahr: [2000]
• Umfang: 10 S.
• Illustrationen: 1 Diagramm
• Fussnoten: Gesehen am 19.05.2021
• Titel Quelle: Enthalten in: Anesthesiology
• Ort Quelle: Hagerstown, Md. : Lippincott Williams & Wilkins, 1940
• Jahr Quelle: 2000
• Band/Heft Quelle: 92(2000), 3, Seite 754-763
• ISSN Quelle: 1528-1175
• DOI: doi:10.1097/00000542-200003000-00019
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1758171642

Abstract

Hypothermia may interfere with the relationship between cerebral blood flow (CBF) and metabolism. Because this conclusion was based on the analysis of global values, the question remains whether hypothermic CBF/metabolism uncoupling exists on a local cerebral level. This study investigated the effects of hypothermic anesthesia on local cerebral blood flow (LCBF) and local cerebral glucose utilization (LCGU).Thirty-six rats were anesthetized with isoflurane (1 minimum alveolar concentration) and artificially ventilated to maintain normal arterial carbon dioxide partial pressure (pH-stat). Pericranial temperature was maintained as normothermic (37.5 degrees C, n = 12) or was reduced to 35 degrees C (n = 12) or 32 degrees C (n = 12). Pericranial temperature was maintained constant for 60 min until LCBF or LCGU were measured by autoradiography. Twelve conscious rats served as normothermic controls.Compared with conscious animals, mean CBF remained unchanged during normothermic anesthesia. Mean CBF significantly increased during mild hypothermia but was unchanged during moderate hypothermia. During normothermic anesthesia, mean CGU was 45% lower than in conscious controls (P < 0.05). No further CGU reduction was found during mild hypothermia, whereas CGU further decreased during moderate hypothermia (48%; P < 0.05). Local analysis showed a linear LCBF/LCGU relationship in conscious (r = 0.94) and anesthetized (r = 0.94) normothermic animals, as well as in both hypothermic groups (35 degrees C: r = 0.92; 32 degrees C: r = 0.95; P < 0.05). The LCBF-to-LCGU ratio increased from 1.4 (conscious controls) to 2.4 (normothermic isoflurane) and 3.6 ml/micromol (mild and moderate hypothermia, P < 0.05).Decrease of mean CGU at unchanged or increased mean CBF during hypothermic anesthesia may not indicate uncoupling. Local analysis shows a maintained linear relationship that is reset to a higher CBF/CGU ratio.