| |  Online-Ressource |
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| Verfasst von: | Lodrini, Marco [VerfasserIn]  |
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| | Oehme, Ina [VerfasserIn] |
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| | Schröder, Christina [VerfasserIn] |
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| | Milde, Till [VerfasserIn] |
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| | Schier, Marie Catherine [VerfasserIn] |
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| | Kopp-Schneider, Annette [VerfasserIn] |
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| | Schulte, Johannes H. [VerfasserIn] |
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| | Fischer, Matthias [VerfasserIn] |
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| | De Preter, Katleen [VerfasserIn] |
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| | Pattyn, Filip [VerfasserIn] |
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| | Castoldi, Mirco [VerfasserIn] |
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| | Muckenthaler, Martina [VerfasserIn] |
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| | Kulozik, Andreas [VerfasserIn] |
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| | Westermann, Frank [VerfasserIn] |
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| | Witt, Olaf [VerfasserIn] |
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| | Deubzer, Hedwig [VerfasserIn] |
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| Titel: | MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma |
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| Verf.angabe: | Marco Lodrini, Ina Oehme, Christina Schroeder, Till Milde, Marie C. Schier, Annette Kopp-Schneider, Johannes H. Schulte, Matthias Fischer, Katleen De Preter, Filip Pattyn, Mirco Castoldi, Martina U. Muckenthaler, Andreas E. Kulozik, Frank Westermann, Olaf Witt and Hedwig E. Deubzer |
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| E-Jahr: | 2013 |
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| Jahr: | 26 April 2013 |
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| Umfang: | 16 S. |
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| Teil: | volume:41 |
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| | year:2013 |
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| | number:12 |
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| | pages:6018-6033 |
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| | extent:16 |
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| Fussnoten: | Gesehen am 19.05.2021 |
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| Titel Quelle: | Enthalten in: Nucleic acids research |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1974 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 41(2013), 12, Seite 6018-6033 |
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| ISSN Quelle: | 1362-4962 |
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| Abstract: | MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183. Enforced miR-183 expression triggered apoptosis, and inhibited anchorage-independent colony formation in vitro and xenograft growth in mice. Furthermore, the mechanism of miR-183 induction was found to contribute to the cell death phenotype induced by HDAC inhibitors. Experiments to identify the HDAC(s) involved in miR-183 transcriptional regulation showed that HDAC2 depletion induced miR-183. HDAC2 overexpression reduced miR-183 levels and counteracted the induction caused by HDAC2 depletion or HDAC inhibitor treatment. MYCN was found to recruit HDAC2 in the same complexes to the miR-183 promoter, and HDAC2 depletion enhanced promoter-associated histone H4 pan-acetylation, suggesting epigenetic changes preceded transcriptional activation. These data reveal miR-183 tumor suppressive properties in neuroblastoma that are jointly repressed by MYCN and HDAC2, and suggest a novel way to bypass MYCN function. |
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| DOI: | doi:10.1093/nar/gkt346 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/nar/gkt346 |
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| | DOI: https://doi.org/10.1093/nar/gkt346 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1758195762 |
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| Verknüpfungen: | → Zeitschrift |
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MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma / Lodrini, Marco [VerfasserIn]; 26 April 2013 (Online-Ressource)
