| |  Online-Ressource |
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| Verfasst von: | Möhler, Thomas [VerfasserIn]  |
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| | Seckinger, Anja [VerfasserIn] |
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| | Hose, Dirk [VerfasserIn] |
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| | Andrulis, Mindaugas [VerfasserIn] |
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| | Moreaux, Jèrôme [VerfasserIn] |
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| | Hielscher, Thomas [VerfasserIn] |
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| | Willhauck-Fleckenstein, Martina [VerfasserIn] |
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| | Merling, Anette [VerfasserIn] |
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| | Bertsch, Uta [VerfasserIn] |
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| | Jauch, Anna [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Klein, Bernard [VerfasserIn] |
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| | Schwartz-Albiez, Reinhard [VerfasserIn] |
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| Titel: | The glycome of normal and malignant plasma cells |
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| Verf.angabe: | Thomas M. Moehler, Anja Seckinger, Dirk Hose, Mindaugas Andrulis, Jèrôme Moreaux, Thomas Hielscher, Martina Willhauck-Fleckenstein, Anette Merling, Uta Bertsch, Anna Jauch, Hartmut Goldschmidt, Bernard Klein, Reinhard Schwartz-Albiez |
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| E-Jahr: | 2013 |
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| Jahr: | December 26, 2013 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 25.05.2021 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 8(2013), 12, Artikel-ID e83719, Seite 1-13 |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including multiple myeloma. Here we analyze the transcriptional differences in the glycome of normal (n = 10) and two cohorts of 332 and 345 malignant plasma-cell samples, association with known multiple myeloma subentities as defined by presence of chromosomal aberrations, potential therapeutic targets, and its prognostic impact. We found i) malignant vs. normal plasma cells to show a characteristic glycome-signature. They can ii) be delineated by a lasso-based predictor from normal plasma cells based on this signature. iii) Cytogenetic aberrations lead to distinct glycan-gene expression patterns for t(11;14), t(4;14), hyperdiploidy, 1q21-gain and deletion of 13q14. iv) A 38-gene glycome-signature significantly delineates patients with adverse survival in two independent cohorts of 545 patients treated with high-dose melphalan and autologous stem cell transplantation. v) As single gene, expression of the phosphatidyl-inositol-glycan protein M as part of the targetable glycosyl-phosphatidyl-inositol-anchor-biosynthesis pathway is associated with adverse survival. The prognostically relevant glycome deviation in malignant cells invites novel strategies of therapy for multiple myeloma. |
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| DOI: | doi:10.1371/journal.pone.0083719 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0083719 |
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| | Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083719 |
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| | DOI: https://doi.org/10.1371/journal.pone.0083719 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biosynthesis |
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| | Bone marrow cells |
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| | Gene expression |
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| | Glycosylation |
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| | Multiple myeloma |
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| | Myeloma cells |
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| | Plasma cells |
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| | Sulfates |
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| K10plus-PPN: | 1758403357 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ glycome of normal and malignant plasma cells / Möhler, Thomas [VerfasserIn]; December 26, 2013 (Online-Ressource)
