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Verfasst von:Tayrouz Haffar, Yorki Antoine [VerfasserIn]   i
 Ding, Reinhard [VerfasserIn]   i
 Burhenne, Jürgen [VerfasserIn]   i
 Riedel, Klaus-Dieter [VerfasserIn]   i
 Weiß, Johanna [VerfasserIn]   i
 Hoppe-Tichy, Torsten [VerfasserIn]   i
 Haefeli, Walter E. [VerfasserIn]   i
 Mikus, Gerd [VerfasserIn]   i
Titel:Pharmacokinetic and pharmaceutic interaction between digoxin and Cremophor RH40
Verf.angabe:Yorki Tayrouz, Reinhard Ding, Jürgen Burhenne, Klaus-Dieter Riedel, Johanna Weiss, Torsten Hoppe-Tichy, Walter Emil Haefeli, Gerd Mikus
E-Jahr:2003
Jahr:17 May 2003
Umfang:9 S.
Teil:volume:73
 year:2003
 number:5
 pages:397-405
 extent:9
Fussnoten:Gesehen am 25.05.2021
Titel Quelle:Enthalten in: Clinical pharmacology & therapeutics
Ort Quelle:Hoboken, NJ : Wiley-Blackwell, 1960
Jahr Quelle:2003
Band/Heft Quelle:73(2003), 5, Seite 397-405
ISSN Quelle:1532-6535
Abstract:Background The pharmacokinetics of digoxin is modulated by the efflux pump P-glycoprotein. Cremophor EL (BASF Aktiengesellschaft, Ludwigshafen, Germany) (polyoxyl 35 castor oil), a castor oil derivative used to improve the solubilization of drugs and vitamins, has been shown to inhibit this membrane transporter in vitro and in vivo. So far, no study in humans has evaluated the effect of Cremophor RH40 (BASF Aktiengesellschaft) (polyoxyl 40 hydrogenated castor oil) on P-glycoprotein. Methods A randomized, double-blind, placebo-controlled crossover study in 12 healthy individuals was performed with a single oral dose of 0.5 mg digoxin in a hard gelatin capsule in combination with multiple doses of oral Cremophor RH40 (600 mg 3 times daily) or placebo. A digitized electrocardiogram with 12 standard leads was recorded to assess the pharmacodynamics of digoxin. Results Cremophor RH40 delayed and enhanced the absorption of digoxin in the first 5 hours after dosing. During Cremophor RH40 administration, digoxin lag time was significantly prolonged compared with placebo (0.53 ± 0.25 hour versus 0.36 ± 0.19 hour, P = .04). The peak concentration of digoxin increased by 22%, from 2.21 ± 0.94 ng/mL to 2.69 ± 1.28 ng/mL (P = .06). Similarly, the area under the plasma concentration-time curve from 0 to 5 hours significantly increased by 22% (5.23 ± 1.63 h · ng/mL versus 4.30 ± 1.12 h · ng/mL, P = .03). Digoxin did not cause a clinically significant change in the dynamic parameters during both periods. Conclusion This study demonstrates a pharmacokinetic and pharmaceutic interaction between the emulgent Cremophor RH40 and digoxin, caused by P-glycoprotein inhibition and prolongation of the dissolution time of digoxin tablets by Cremophor RH40, respectively. Our in vivo study in humans supports the validity of in vitro observations on P-glycoprotein. Clinical Pharmacology & Therapeutics (2003) 73, 397-405; doi: 10.1016/S0009-9236(03)00059-6
DOI:doi:10.1016/S0009-9236(03)00059-6
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/https://doi.org/10.1016/S0009-9236(03)00059-6
 Volltext: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/S0009-9236%2803%2900059-6
 DOI: https://doi.org/10.1016/S0009-9236(03)00059-6
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1758439858
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