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| Online-Ressource |
Verfasst von: | Lindner, Holger A. [VerfasserIn]  |
| Velásquez, Sonia Y. [VerfasserIn]  |
| Thiel, Manfred [VerfasserIn]  |
| Kirschning, Thomas [VerfasserIn]  |
Titel: | Lung protection vs. infection resolution |
Titelzusatz: | Interleukin 10 suspected of double-dealing in COVID-19 |
Verf.angabe: | Holger A. Lindner, Sonia Y. Velásquez, Manfred Thiel and Thomas Kirschning |
E-Jahr: | 2021 |
Jahr: | 03 March 2021 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 25.05.2021 |
Titel Quelle: | Enthalten in: Frontiers in immunology |
Ort Quelle: | Lausanne : Frontiers Media, 2010 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 12(2021) vom: 3. März, Artikel-ID 602130 |
ISSN Quelle: | 1664-3224 |
Abstract: | The pathological processes by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that make the virus a major threat to global health are insufficiently understood. Inefficient viral clearance at any stage is a hallmark of coronavirus disease 2019 (COVID-19). Disease severity is associated with increases in peripheral blood cytokines among which interleukin 10 (IL-10) increases particularly early and independent of patient age, which is not seen in active SARS-CoV infection. Here, we consider the known multi-faceted immune regulatory role of IL-10, both in protecting the lung from injury and in defense against infections, as well as its potential cellular source. While the absence of an IL-10 response in SARS is thought to contribute to early deterioration, we suspect IL-10 to protect the lung from early immune-mediated damage and to interfere with viral clearance in COVID-19. This may further both viral spread and poor outcome in many high-risk patients. Identifying the features of the viral genotype, which specifically underlie the different IL-10 dynamics as an etiological endotype and the different viral load kinetics and outcomes as clinical phenotype, may unveil a new immune evasive strategy of SARS-CoV-2. |
DOI: | doi:10.3389/fimmu.2021.602130 |
URL: | kostenfrei: Volltext: https://doi.org/10.3389/fimmu.2021.602130 |
| kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2021.602130/full |
| DOI: https://doi.org/10.3389/fimmu.2021.602130 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1758445947 |
Verknüpfungen: | → Zeitschrift |
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Lokale URL UB: | Zum Volltext |
Lung protection vs. infection resolution / Lindner, Holger A. [VerfasserIn]; 03 March 2021 (Online-Ressource)
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