Lung protection vs. infection resolution

• Verfasst von: Lindner, Holger A. [VerfasserIn]
• Verfasst von: Velásquez, Sonia Y. [VerfasserIn]
• Verfasst von: Thiel, Manfred [VerfasserIn]
• Verfasst von: Kirschning, Thomas [VerfasserIn]
• Titel: Lung protection vs. infection resolution
• Titelzusatz: Interleukin 10 suspected of double-dealing in COVID-19
• Verf.angabe: Holger A. Lindner, Sonia Y. Velásquez, Manfred Thiel and Thomas Kirschning
• E-Jahr: 2021
• Jahr: 03 March 2021
• Umfang: 11 S.
• Fussnoten: Gesehen am 25.05.2021
• Titel Quelle: Enthalten in: Frontiers in immunology
• Ort Quelle: Lausanne : Frontiers Media, 2010
• Jahr Quelle: 2021
• Band/Heft Quelle: 12(2021) vom: 3. März, Artikel-ID 602130
• ISSN Quelle: 1664-3224
• DOI: doi:10.3389/fimmu.2021.602130
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1758445947
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

The pathological processes by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that make the virus a major threat to global health are insufficiently understood. Inefficient viral clearance at any stage is a hallmark of coronavirus disease 2019 (COVID-19). Disease severity is associated with increases in peripheral blood cytokines among which interleukin 10 (IL-10) increases particularly early and independent of patient age, which is not seen in active SARS-CoV infection. Here, we consider the known multi-faceted immune regulatory role of IL-10, both in protecting the lung from injury and in defense against infections, as well as its potential cellular source. While the absence of an IL-10 response in SARS is thought to contribute to early deterioration, we suspect IL-10 to protect the lung from early immune-mediated damage and to interfere with viral clearance in COVID-19. This may further both viral spread and poor outcome in many high-risk patients. Identifying the features of the viral genotype, which specifically underlie the different IL-10 dynamics as an etiological endotype and the different viral load kinetics and outcomes as clinical phenotype, may unveil a new immune evasive strategy of SARS-CoV-2.