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Verfasst von:Lindner, Holger A. [VerfasserIn]   i
 Velásquez, Sonia Y. [VerfasserIn]   i
 Thiel, Manfred [VerfasserIn]   i
 Kirschning, Thomas [VerfasserIn]   i
Titel:Lung protection vs. infection resolution
Titelzusatz:Interleukin 10 suspected of double-dealing in COVID-19
Verf.angabe:Holger A. Lindner, Sonia Y. Velásquez, Manfred Thiel and Thomas Kirschning
E-Jahr:2021
Jahr:03 March 2021
Umfang:11 S.
Fussnoten:Gesehen am 25.05.2021
Titel Quelle:Enthalten in: Frontiers in immunology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2021
Band/Heft Quelle:12(2021) vom: 3. März, Artikel-ID 602130
ISSN Quelle:1664-3224
Abstract:The pathological processes by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that make the virus a major threat to global health are insufficiently understood. Inefficient viral clearance at any stage is a hallmark of coronavirus disease 2019 (COVID-19). Disease severity is associated with increases in peripheral blood cytokines among which interleukin 10 (IL-10) increases particularly early and independent of patient age, which is not seen in active SARS-CoV infection. Here, we consider the known multi-faceted immune regulatory role of IL-10, both in protecting the lung from injury and in defense against infections, as well as its potential cellular source. While the absence of an IL-10 response in SARS is thought to contribute to early deterioration, we suspect IL-10 to protect the lung from early immune-mediated damage and to interfere with viral clearance in COVID-19. This may further both viral spread and poor outcome in many high-risk patients. Identifying the features of the viral genotype, which specifically underlie the different IL-10 dynamics as an etiological endotype and the different viral load kinetics and outcomes as clinical phenotype, may unveil a new immune evasive strategy of SARS-CoV-2.
DOI:doi:10.3389/fimmu.2021.602130
URL:kostenfrei: Volltext: https://doi.org/10.3389/fimmu.2021.602130
 kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2021.602130/full
 DOI: https://doi.org/10.3389/fimmu.2021.602130
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1758445947
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