| |  Online-Ressource |
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| Verfasst von: | Uysal, Daniel [VerfasserIn]  |
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| | Egen, Luisa [VerfasserIn] |
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| | Grilli, Maurizio [VerfasserIn] |
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| | Wessels, Frederik [VerfasserIn] |
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| | Lenhart, Maximilian [VerfasserIn] |
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| | Michel, Maurice Stephan [VerfasserIn] |
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| | Kriegmair, Maximilian [VerfasserIn] |
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| | Kowalewski, Karl-Friedrich [VerfasserIn] |
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| Titel: | Impact of perioperative blood transfusions on oncologic outcomes after radical cystectomy |
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| Titelzusatz: | a systematic review and meta-analysis of comparative studies |
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| Verf.angabe: | D. Uysal, L. Egen, M. Grilli, F. Wessels, M. Lenhart, M.S. Michel, M.C. Kriegmair, K.F. Kowalewski |
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| E-Jahr: | 2021 |
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| Jahr: | September 2021 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 26.05.2021 |
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| Titel Quelle: | Enthalten in: Surgical oncology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1992 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 38(2021), Artikel-ID 101592, Seite 1-9 |
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| ISSN Quelle: | 1879-3320 |
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| Abstract: | This study aimed at systematically analyzing and evaluating the impact of perioperative blood transfusions (PBT) on oncologic outcomes of patients undergoing radical cystectomy for bladder cancer. This systematic review follows the recommendations of the Cochrane Handbook for Systematic Reviews and Interventions and was conducted in line with the PRISMA statement and the AMSTAR II criteria. A comprehensive database search was performed based on the PICO criteria. Two independent reviewers performed all screening steps and quality assessment. Risk of bias and certainty in evidence were assessed with the Newcastle Ottawa Scale for non-randomized trials and the GRADE approach. Of 1123 identified studies 20 were eligible for qualitative analysis and 15 for quantitative analysis reporting on 21,915 patients. Receiving a PBT was associated with an increased risk of all-cause mortality (hazard ratio (HR) [95% confidence interval (CI)]: 1.29 [1.18, 1.40]; p < 0.001), cancer-specific mortality (HR [CI]: 1.27 [1.15; 1.41]; p < 0.001) and disease recurrence (HR [CI]: 1.22 [1.12; 1.34]; p < 0.001). Subgroup analysis of transfusion timing revealed a significantly increased risk of mortality with intraoperative or combined intra- and postoperative transfusions compared to postoperative transfusion only for all three outcomes (p < 0.001). Leukocyte-depletion was associated with increased all-cause mortality, but not cancer-specific mortality. The administration of PBT negatively impacts oncological outcomes after radical cystectomy. Therefore, careful treatment indication and strict adherence to transfusion guidelines is encouraged in order to avoid adverse effects during the perioperative course. |
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| DOI: | doi:10.1016/j.suronc.2021.101592 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.suronc.2021.101592 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0960740421000815 |
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| | DOI: https://doi.org/10.1016/j.suronc.2021.101592 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bladder cancer |
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| | Blood transfusion |
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| | Cystectomy |
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| | Meta-analysis |
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| | Oncology |
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| | Systematic review |
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| K10plus-PPN: | 1758940212 |
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| Verknüpfungen: | → Zeitschrift |
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Impact of perioperative blood transfusions on oncologic outcomes after radical cystectomy / Uysal, Daniel [VerfasserIn]; September 2021 (Online-Ressource)
