Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Romerio, Silvana C. [VerfasserIn]  |
|---|
| | Linder-Schönenberger, Lilly [VerfasserIn] |
|---|
| | Haefeli, Walter E. [VerfasserIn] |
|---|
| Titel: | Neurokinin-1 receptor antagonist R116301 inhibits substance P-induced venodilation |
|---|
| Verf.angabe: | Silvana C. Romerio, Lilly Linder, and Walter E. Haefeli |
|---|
| E-Jahr: | 1999 |
|---|
| Jahr: | 25 November 1999 |
|---|
| Umfang: | 6 S. |
|---|
| Teil: | volume:66 |
|---|
| | year:1999 |
|---|
| | number:5 |
|---|
| | pages:522-527 |
|---|
| | extent:6 |
|---|
| Fussnoten: | Gesehen am 27.05.2021 |
|---|
| Titel Quelle: | Enthalten in: Clinical pharmacology & therapeutics |
|---|
| Ort Quelle: | Hoboken, NJ : Wiley-Blackwell, 1960 |
|---|
| Jahr Quelle: | 1999 |
|---|
| Band/Heft Quelle: | 66(1999), 5, Seite 522-527 |
|---|
| ISSN Quelle: | 1532-6535 |
|---|
| Abstract: | Objective To test the effect of the neurokinin-1 receptor antagonist hydroxybutanedioate (R116301) in human hand veins in vivo. Methods In a randomized, double-blind, placebo-controlled crossover study we used the hand vein compliance method to evaluate the inhibition of the response to substance P by R116301. Results In hand veins preconstricted with phenylephrine to 21% ± 2.6% (mean ± SEM, placebo) and 25% ± 3.0% (R116301) of the initial diameter, substance P resulted in a mean venodilation of 84% ± 7% and 87% ± 13% (P = .8) before administration of placebo and R116301, respectively. Oral administration of 300 mg R116301 resulted in peak plasma concentrations of 1.16 ± 0.1 ¼g/mL within 128 ± 14 minutes. With increasing R116301 plasma concentrations, substance P-induced venodilation decreased significantly (P < .001), whereas placebo had no effect. Mean substance P-induced venodilation was markedly reduced to 8% ± 7%. Conclusion This study confirms the presence of neurokinin-1 receptors in human veins and the effectiveness of the neurokinin-1 receptor antagonist R116301 in human hand veins. Clinical Pharmacology & Therapeutics (1999) 66, 522-527; doi: |
|---|
| DOI: | doi:10.1016/S0009-9236(99)70016-0 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/https://doi.org/10.1016/S0009-9236(99)70016-0 |
|---|
| | Volltext: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/S0009-9236%2899%2970016-0 |
|---|
| | DOI: https://doi.org/10.1016/S0009-9236(99)70016-0 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1759027006 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Neurokinin-1 receptor antagonist R116301 inhibits substance P-induced venodilation / Romerio, Silvana C. [VerfasserIn]; 25 November 1999 (Online-Ressource)
68741508
