| |  Online-Ressource |
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| Verfasst von: | Loehrer, Franziska [VerfasserIn]  |
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| | Tschöpl, Martin [VerfasserIn] |
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| | Angst, Christian Peter [VerfasserIn] |
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| | Litynski, Piotr [VerfasserIn] |
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| | Jäger, Kurt [VerfasserIn] |
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| | Fowler, Brian [VerfasserIn] |
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| | Haefeli, Walter E. [VerfasserIn] |
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| Titel: | Disturbed ratio of erythrocyte and plasma S-adenosylmethionine/S-adenosylhomocysteine in peripheral arterial occlusive disease |
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| Verf.angabe: | Franziska M. T Loehrer, Martin Tschöpl, Christian P Angst, Piotr Litynski, Kurt Jäger, Brian Fowler, Walter E Haefeli |
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| Jahr: | 2001 |
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| Umfang: | 8 S. |
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| Teil: | volume:154 |
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| | year:2001 |
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| | number:1 |
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| | pages:147-154 |
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| | extent:8 |
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| Fussnoten: | Online 21 December 2000 ; Gesehen am 27.05.2021 |
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| Titel Quelle: | Enthalten in: Atherosclerosis |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1970 |
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| Jahr Quelle: | 2001 |
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| Band/Heft Quelle: | 154(2001), 1, Seite 147-154 |
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| ISSN Quelle: | 1879-1484 |
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| Abstract: | Altered homocysteine metabolism associated with peripheral arterial occlusive disease (PAOD) may lead to impairment of vital methylation reactions through accumulation of S-adenosylhomocysteine (AdoHcy) as well as through alteration of the ratio S-adenosylmethionine (AdoMet)/AdoHcy. We determined AdoMet, AdoHcy, their ratio, and homocysteine in plasma as well as AdoMet, AdoHcy, and their ratio in erythrocytes of 61 patients with PAOD (age 49-93) and 50 healthy controls (age 41-87). Geometric mean values of plasma homocysteine, AdoMet, and AdoHcy were significantly increased in patients compared with controls (15.5 vs. 10.4 μmol/l**; 107 vs. 52.3* nmol/l; 55.0 vs. 23.1** nmol/l, respectively; *P<0.01, **P<0.001), while the ratio of AdoMet/AdoHcy was decreased in patients (1.92 vs. 2.52*). In erythrocytes patients exhibited increased levels of AdoHcy compared with controls (309 vs. 205 nmol/l**) whereas AdoMet (3351 vs. 3732 nmol/l*) and the ratio of AdoMet/AdoHcy (11.8 vs. 19.1**) were decreased. The odds ratio (OR) for developing PAOD with decreased AdoMet/AdoHcy ratio after adjustment for kidney function was significant for erythrocyte levels ≤14.2 (OR, 7.1 (6.9-7.2, 95% CI). In addition, hematocrit levels were found to be significantly decreased in patients versus controls (0.35 vs. 0.42 l/l**) and were significantly correlated with the ratio of AdoMet/AdoHcy in erythrocytes of the patients. Since the ratio of AdoMet/AdoHcy is closely linked with the activity of numerous enzymatic methylation reactions, these results suggest that methylation may be impaired in these patients. |
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| DOI: | doi:10.1016/S0021-9150(00)00449-4 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S0021-9150(00)00449-4 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0021915000004494 |
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| | DOI: https://doi.org/10.1016/S0021-9150(00)00449-4 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | -Adenosylhomocysteine |
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| | -Adenosylmethionine |
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| | Erythrocytes |
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| | High performance liquid chromatography |
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| | Homocysteine |
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| | Methylation |
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| | Peripheral arterial occlusive disease |
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| K10plus-PPN: | 1759027219 |
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| Verknüpfungen: | → Zeitschrift |
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Disturbed ratio of erythrocyte and plasma S-adenosylmethionine/S-adenosylhomocysteine in peripheral arterial occlusive disease / Loehrer, Franziska [VerfasserIn]; 2001 (Online-Ressource)
