Changes in the serum proteome of patients with sepsis and septic shock

• Verfasst von: Kalenka, Armin [VerfasserIn]
• Verfasst von: Feldmann, Robert Enrico [VerfasserIn]
• Verfasst von: Otero-Scheibelhofer, Kevin [VerfasserIn]
• Verfasst von: Maurer, Martin H. [VerfasserIn]
• Verfasst von: Waschke, Klaus F. [VerfasserIn]
• Verfasst von: Fiedler, Fritz [VerfasserIn]
• Titel: Changes in the serum proteome of patients with sepsis and septic shock
• Verf.angabe: Armin Kalenka, Robert E. Jr Feldmann, Kevin Otero, Martin H. Maurer, Klaus F. Waschke, Fritz Fiedler
• E-Jahr: 2006
• Jahr: [December 2006]
• Umfang: 5 S.
• Illustrationen: 1 Illustration
• Fussnoten: Gesehen am 28.05.2021
• Titel Quelle: Enthalten in: Anesthesia & analgesia
• Ort Quelle: Baltimore, Md. : Williams & Wilkins, 1957
• Jahr Quelle: 2006
• Band/Heft Quelle: 103(2006), 6 vom: Dez., Seite 1522-1526
• ISSN Quelle: 1526-7598
• DOI: doi:10.1213/01.ane.0000242533.59457.70
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1759097543

Abstract

BACKGROUND: - Sepsis is still the leading cause of death in the intensive care unit. Our goal was to elucidate potential early differences in serum between survivors (SURV) and non-survivors (NON-SURV) on day 28. - METHODS: - We applied proteomic technology to serum samples of patients with sepsis and septic shock. Serum samples from 18 patients with sepsis and septic shock were obtained during the first 12 h after diagnosis of septic shock. Patients were grouped into SURV and NON-SURV on day 28. - RESULTS: - Seven patients survived and 11 patients died. Using proteome analysis, two-dimensional gel electrophoresis detected more than 200 spots per gel. A differential protein expression was discovered between SURV and NON-SURV, whereby protein alterations not yet described in sepsis were revealed. - CONCLUSIONS: - Our results show that proteomic profiling is a useful approach for detecting protein expression dynamics in septic patients, and may bring us closer to achieving a comprehensive molecular profiling compared with genetic studies alone.