Local transport kinetics of glucose during acute and chronic nicotine infusion in rat brains

• Verfasst von: Duelli, Roman [VerfasserIn]
• Verfasst von: Staudt, Richard Erhard [VerfasserIn]
• Verfasst von: Maurer, Martin H. [VerfasserIn]
• Verfasst von: Kuschinsky, Wolfgang [VerfasserIn]
• Titel: Local transport kinetics of glucose during acute and chronic nicotine infusion in rat brains
• Verf.angabe: R. Duelli, R. Staudt, M.H. Maurer, and W. Kuschinsky
• E-Jahr: 1998
• Jahr: [1998]
• Umfang: 12 S.
• Fussnoten: Gesehen am 28.05.2021
• Titel Quelle: Enthalten in: Journal of neural transmission
• Ort Quelle: Wien [u.a.] : Springer, 1950
• Jahr Quelle: 1998
• Band/Heft Quelle: 105(1998), 8, Seite 1017-1028
• ISSN Quelle: 1435-1463
• DOI: doi:10.1007/s007020050109
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1759109479

Abstract

Acute and chronic infusion of nicotine is known to result in a distinct increase in local cerebral glucose utilization (LCGU) in several brain structures. The present study addresses the question whether this increase in LCGU is paralleled by a local change in glucose transport in rat brain. Nicotine was infused either acutely for 3 hours or chronically by osmotic minipumps for one week. Local rate constants for glucose transport were measured in brain cryosections using the 3-O-[14C]methylglucose method. Local rate constants K1 and k2 were lower in part of the brain structures during acute (−10% to −20%) and in nearly all structures during chronic (−39% to −41%) nicotine. The finding of a decreased glucose transport during chronic nicotine was confirmed by additional experiments of 3-O-[14C]methylglucose transfer in an epithelial cell culture. It is concluded that acute and chronic nicotine infusion results in decreased glucose transport although LCGU is either unchanged or increased.