Status: Bibliographieeintrag
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| Verfasst von: | Klawonn, Frank [VerfasserIn]  |
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| | Hoffmann, Georg [VerfasserIn] |
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| | Orth, Matthias [VerfasserIn] |
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| Titel: | Quantitative laboratory results |
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| Titelzusatz: | normal or lognormal distribution? |
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| Verf.angabe: | Frank Klawonn, Georg Hoffmann and Matthias Orth |
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| E-Jahr: | 2020 |
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| Jahr: | 4. Juni 2020 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 28.05.2021 |
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| Titel Quelle: | Enthalten in: Journal of laboratory medicine |
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| Ort Quelle: | Berlin : De Gruyter, 2018 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 44(2020), 3, Seite 143-150 |
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| ISSN Quelle: | 2567-9449 |
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| Abstract: | The identification of a suitable distribution model is a prerequisite for the parametric estimation of reference intervals and other statistical laboratory tasks. Classification of normal vs. lognormal distributions from healthy populations is easy, but from mixed populations, containing unknown proportions of abnormal results, it is challenging. We demonstrate that Bowley's skewness coefficient differentiates between normal and lognormal distributions. This classifier is robust and easy to calculate from the quartiles Q1-Q3 according to the formula (Q1- 2 . Q2+ Q3)/(Q3 - Q1). We validate our algorithm with a more complex procedure, which optimizes the exponent A of a power transformation. As a practical application, we show that Bowley's skewness coefficient is suited selecting the adequate distribution model for the estimation of reference limits according to a recent International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommendation, especially if the data is right-skewed. |
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| DOI: | doi:10.1515/labmed-2020-0005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1515/labmed-2020-0005 |
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| | DOI: https://doi.org/10.1515/labmed-2020-0005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | alat |
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| | Bowley's skewness |
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| | creatinine |
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| | hemoglobin |
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| | leukocytes |
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| | limits |
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| | lognormal distribution |
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| | normal distribution |
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| | plasma electrolyte |
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| | potassium |
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| | power transformation |
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| | quartile skewness |
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| | sodium |
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| K10plus-PPN: | 1759156469 |
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| Verknüpfungen: | → Zeitschrift |
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Quantitative laboratory results / Klawonn, Frank [VerfasserIn]; 4. Juni 2020 (Online-Ressource)
68742055
