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| Verfasst von: | Riemann, Sarah [VerfasserIn]  |
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| | Kolibabka, Matthias [VerfasserIn] |
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| | Busch, Stephanie [VerfasserIn] |
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| | Lin, Jihong [VerfasserIn] |
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| | Hoffmann, Sigrid [VerfasserIn] |
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| | Gretz, Norbert [VerfasserIn] |
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| | Feng, Yuxi [VerfasserIn] |
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| | Wohlfart, Paulus [VerfasserIn] |
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| | Hammes, Hans-Peter [VerfasserIn] |
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| Titel: | Microglial activation is associated with vasoprotection in a rat model of inflammatory retinal vasoregression |
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| Verf.angabe: | Sarah Riemann, Matthias Kolibabka, Stephanie Busch, Jihong Lin, Sigrid Hoffmann, Norbert Gretz, Yuxi Feng, Paulus Wohlfart and Hans-Peter Hammes |
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| E-Jahr: | 2021 |
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| Jahr: | 26 April 2021 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 29.05.2021 |
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| Titel Quelle: | Enthalten in: Frontiers in physiology |
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| Ort Quelle: | Lausanne : Frontiers Research Foundation, 2007 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021) vom: 26. Apr., Artikel-ID 660164 |
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| ISSN Quelle: | 1664-042X |
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| Abstract: | Vascular dysfunction and vasoregression are hallmarks of a variety of inflammatory central nervous system disorders and inflammation related retinal diseases like diabetic retinopathy. Activation of microglia and the humoral innate immune system are contributing factors. Anti-inflammatory approaches have been proposed as therapies for neurovascular diseases, which includes the modulation of microglial activation. The present study aimed at investigating the effects of microglial activation by clodronate-coated liposomes on vasoregression in a model of retinal degeneration. Clodronate treatment over 5 weeks led to an increase in activated CD74+ microglia and completely prevented acellular capillaries and pericyte loss. Gene expression analyses indicated that vasoprotection was due to the induction of vasoprotective factors such as Egr1, Stat3 and Ahr while expression of pro-inflammatory genes remained unchanged. We conclude that activated microglia lead to a shift towards induction of pleiotropic protective pathways supporting vasoprotection in neurovascular retinal disease. |
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| DOI: | doi:10.3389/fphys.2021.660164 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.3389/fphys.2021.660164 |
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| | kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fphys.2021.660164/full |
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| | DOI: https://doi.org/10.3389/fphys.2021.660164 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Clodronate |
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| | Microglia |
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| | pericyte |
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| | retinopathy |
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| | Vasoregression |
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| K10plus-PPN: | 1759181730 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Microglial activation is associated with vasoprotection in a rat model of inflammatory retinal vasoregression / Riemann, Sarah [VerfasserIn]; 26 April 2021 (Online-Ressource)
