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| Verfasst von: | Kalinichenko, Liubov [VerfasserIn]  |
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| | Abdel-Hafiz, Laila [VerfasserIn] |
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| | Wang, An-Li [VerfasserIn] |
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| | Mühle, Christiane [VerfasserIn] |
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| | Rösel, Nadine [VerfasserIn] |
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| | Schumacher, Fabian [VerfasserIn] |
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| | Kleuser, Burkhard [VerfasserIn] |
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| | Smaga, Irena [VerfasserIn] |
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| | Frankowska, Malgorzata [VerfasserIn] |
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| | Filip, Malgorzata [VerfasserIn] |
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| | Schaller, Gerd [VerfasserIn] |
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| | Richter-Schmidinger, Tanja [VerfasserIn] |
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| | Lenz, Bernd [VerfasserIn] |
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| | Gulbins, Erich [VerfasserIn] |
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| | Kornhuber, Johannes [VerfasserIn] |
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| | Oliveira, André W C [VerfasserIn] |
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| | Barros, Marilia [VerfasserIn] |
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| | Huston, Joseph P [VerfasserIn] |
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| | Müller, Christian P [VerfasserIn] |
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| Titel: | Neutral sphingomyelinase is an affective valence-dependent regulator of learning and memory |
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| Verf.angabe: | Liubov S Kalinichenko, Laila Abdel-Hafiz, An-Li Wang, Christiane Mühle, Nadine Rösel, Fabian Schumacher, Burkhard Kleuser, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Gerd Schaller, Tanja Richter-Schmidinger, Bernd Lenz, Erich Gulbins, Johannes Kornhuber, André W C Oliveira, Marilia Barros, Joseph P Huston and Christian P Müller |
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| E-Jahr: | 2021 |
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| Jahr: | February 2021 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 31.05.2021 |
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| Titel Quelle: | Enthalten in: Cerebral cortex |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1991 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 31(2021), 2, Seite 1316-1333 |
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| ISSN Quelle: | 1460-2199 |
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| Abstract: | Sphingolipids and enzymes of the sphingolipid rheostat determine synaptic appearance and signaling in the brain, but sphingolipid contribution to normal behavioral plasticity is little understood. Here we asked how the sphingolipid rheostat contributes to learning and memory of various dimensions. We investigated the role of these lipids in the mechanisms of two different types of memory, such as appetitively and aversively motivated memory, which are considered to be mediated by different neural mechanisms. We found an association between superior performance in short- and long-term appetitively motivated learning and regionally enhanced neutral sphingomyelinase (NSM) activity. An opposite interaction was observed in an aversively motivated task. A valence-dissociating role of NSM in learning was confirmed in mice with genetically reduced NSM activity. This role may be mediated by the NSM control of N-methyl-d-aspartate receptor subunit expression. In a translational approach, we confirmed a positive association of serum NSM activity with long-term appetitively motivated memory in nonhuman primates and in healthy humans. Altogether, these data suggest a new sphingolipid mechanism of de-novo learning and memory, which is based on NSM activity. |
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| DOI: | doi:10.1093/cercor/bhaa298 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/cercor/bhaa298 |
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| | DOI: https://doi.org/10.1093/cercor/bhaa298 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1759243132 |
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| Verknüpfungen: | → Zeitschrift |
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Neutral sphingomyelinase is an affective valence-dependent regulator of learning and memory / Kalinichenko, Liubov [VerfasserIn]; February 2021 (Online-Ressource)
