| |  Online-Ressource |
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| Verfasst von: | Janke, Eva [VerfasserIn]  |
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| | Groh, Adrian [VerfasserIn] |
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| | Mühle, Christiane [VerfasserIn] |
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| | Dürsteler-MacFarland, Kenneth M. [VerfasserIn] |
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| | Wiesbeck, Gerhard A. [VerfasserIn] |
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| | Kornhuber, Johannes [VerfasserIn] |
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| | Jahn, Kirsten [VerfasserIn] |
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| | Groeschl, Michael [VerfasserIn] |
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| | Lichtinghagen, Ralf [VerfasserIn] |
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| | Frieling, Helge [VerfasserIn] |
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| | Bleich, Stefan [VerfasserIn] |
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| | Hillemacher, Thomas [VerfasserIn] |
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| | Lenz, Bernd [VerfasserIn] |
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| | Heberlein, Annemarie [VerfasserIn] |
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| Titel: | Association of testosterone levels and steroid 5-alpha-reductase 2 polymorphisms with opioid craving |
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| Verf.angabe: | Eva Janke, Adrian Groh, Christiane Mühle, Kenneth M. Dürsteler-MacFarland, Gerhard A. Wiesbeck, Johannes Kornhuber, Kirsten Jahn, Michael Groeschl, Ralf Lichtinghagen, Helge Frieling, Stefan Bleich, Thomas Hillemacher, Bernd Lenz, Annemarie Heberlein |
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| E-Jahr: | 2021 |
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| Jahr: | February 2021 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 01.06.2021 |
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| Titel Quelle: | Enthalten in: Neuropsychobiology |
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| Ort Quelle: | Basel : Karger, 1975 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 80(2021), 1, Seite 64-73 |
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| ISSN Quelle: | 1423-0224 |
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| Abstract: | Background/Aims: Opioid dependence is a severe disease which is associated with a high risk of relapse, even in cases of successful withdrawal therapy. Studies have shown alterations of the hypothalamic-pituitary-gonadal axis in opioid-dependent patients, such as decreased testosterone serum levels in affected males. Sex hormones and the steroid 5-alpha-reductase 2 (SRD5A2) V89L polymorphism are associated with craving during alcohol withdrawal, but little is known about their impact on symptomatology of opioid dependence. Methods: In this study, we analyzed 2 independent male cohorts of opioid-dependent patients for possible alterations in testosterone serum levels compared to non-opioid-dependent controls. In one of the cohorts, we additionally investigated associations of testosterone serum levels and 3 SRD5A2 polymorphisms with symptoms of opioid dependence, measured by the Heroin Craving Questionnaire (HCQ). Results: In the patient groups, we found significantly decreased testosterone serum levels compared to the control groups. Furthermore, we found significant associations of both the testosterone serum levels and the SRD5A2 V89L polymorphism with opioid craving assessed by the HCQ. Conclusion: Our data show a possible role of testosterone metabolism in opioid dependence, which may be relevant for the establishment of future treatment strategies. |
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| DOI: | doi:10.1159/000508681 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000508681 |
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| | Volltext: https://www.karger.com/Article/FullText/508681 |
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| | DOI: https://doi.org/10.1159/000508681 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1759260657 |
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| Verknüpfungen: | → Zeitschrift |
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Association of testosterone levels and steroid 5-alpha-reductase 2 polymorphisms with opioid craving / Janke, Eva [VerfasserIn]; February 2021 (Online-Ressource)
