Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Heinold, Andreas [VerfasserIn]   i
 Opelz, Gerhard [VerfasserIn]   i
 Döhler, Bernd [VerfasserIn]   i
 Scherer, Sabine [VerfasserIn]   i
 Ruhenstroth, Andrea [VerfasserIn]   i
 Tran, Thuong Hien [VerfasserIn]   i
Titel:Genetic polymorphisms of adhesion molecules and kidney transplant survival
Verf.angabe:Andreas Heinold, Gerhard Opelz, Bernd Döhler, Sabine Scherer, Andrea Ruhenstroth, and Thuong Hien Tran
Jahr:2010
Umfang:9 S.
Teil:volume:89
 year:2010
 number:9
 pages:1079-1087
 extent:9
Fussnoten:Gesehen am 02.06.2021
Titel Quelle:Enthalten in: Transplantation
Ort Quelle:Hagerstown, Md. : Lippincott Williams & Wilkins, 1963
Jahr Quelle:2010
Band/Heft Quelle:89(2010), 9, Seite 1079-1087
ISSN Quelle:1534-6080
Abstract:BACKGROUND.: Adhesion molecules play a key role in the recruitment of leukocytes to sites of inflammation. Genetic polymorphisms of adhesion molecules may alter their expression or function and may thereby influence the process of leukocyte infiltration in the transplanted organ. It has also been suggested that polymorphic adhesion molecules may act as minor histocompatibility antigens. METHODS.: In two randomly selected cohorts (954 and 1002 kidney transplants), the effect of L-selectin/CD62L (codon 206 and 213), platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31; codon 125, 563, and 670), and activated leukocyte cell adhesion molecule (ALCAM/CD166; codon 258) single nucleotide polymorphisms on 5-yr allograft survival was investigated. DNA samples and clinical data were provided by the Collaborative Transplant Study. Recipients and donors were genotyped by polymerase chain reaction sequence-specific primer. A multivariate analysis was performed using a Cox regression model. RESULTS.: Incompatibility for L-selectin at codon 213 was significantly associated with better graft survival in the first cohort, but the effect could not be replicated in the second cohort. Polymorphisms of PECAM-1 and ALCAM had no impact on graft outcome. CONCLUSIONS.: This is the first comprehensive and large-scale study on the relevance of L-selectin, PECAM-1, and ALCAM genetic polymorphisms in kidney transplantation, showing no significant associations of recipient or donor genotypes with allograft survival. Because the effect of L-selectin mismatch was not reproducible, a putative role of adhesion molecules as minor histocompatibility antigens cannot be confirmed. Our results demonstrate the importance of testing large sample sizes and of performing confirmation studies to validate genetic associations.
DOI:doi:10.1097/TP.0b013e3181d3c9ee
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1097/TP.0b013e3181d3c9ee
 Volltext: https://journals.lww.com/transplantjournal/Fulltext/2010/05150/Genetic_Polymorphisms_of_Adhesion_Molecules_and.5.aspx
 DOI: https://doi.org/10.1097/TP.0b013e3181d3c9ee
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Activated-Leukocyte Cell Adhesion Molecule
 Adult
 Cadaver
 Codon
 Databases, Nucleic Acid
 DNA Primers
 European Continental Ancestry Group
 Female
 Graft Survival
 HLA-A Antigens
 HLA-B Antigens
 HLA-DR Antigens
 Humans
 Kidney Transplantation
 L-Selectin
 Male
 Middle Aged
 Patient Selection
 Platelet Endothelial Cell Adhesion Molecule-1
 Polymerase Chain Reaction
 Polymorphism, Genetic
 Tissue Donors
 Transplantation, Homologous
K10plus-PPN:1759434329
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68744175   QR-Code
zum Seitenanfang