| |  Online-Ressource |
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| Verfasst von: | Tran, Thuong Hien [VerfasserIn]  |
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| | Döhler, Bernd [VerfasserIn] |
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| | Heinold, Andreas [VerfasserIn] |
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| | Scherer, Sabine [VerfasserIn] |
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| | Ruhenstroth, Andrea [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| Titel: | Deleterious impact of mismatching for human leukocyte antigen-C in presensitized recipients of kidney transplants |
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| Verf.angabe: | Thuong Hien Tran, Bernd Döhler, Andreas Heinold, Sabine Scherer, Andrea Ruhenstroth, and Gerhard Opelz |
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| Jahr: | 2011 |
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| Umfang: | 7 S. |
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| Teil: | volume:92 |
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| | year:2011 |
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| | number:4 |
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| | pages:419-425 |
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| | extent:7 |
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| Fussnoten: | Gesehen am 02.06.2021 |
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| Titel Quelle: | Enthalten in: Transplantation |
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| Ort Quelle: | Hagerstown, Md. : Lippincott Williams & Wilkins, 1963 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 92(2011), 4, Seite 419-425 |
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| ISSN Quelle: | 1534-6080 |
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| Abstract: | BACKGROUND: Allocation of deceased donor kidneys is commonly based on matching for human leukocyte antigen (HLA)-A, -B, and -DR, whereas HLA-C is currently disregarded. We investigated the influence of HLA-C compatibility on renal allograft survival. In addition, we tested an approach of matching for HLA-C epitopes. METHODS: A cohort of 2260 deceased donor kidney transplants were typed for HLA-C using polymerase chain reaction-sequence specific primer method. Samples for DNA typing, serum results on presensitization (lymphocytotoxicity), and clinical data were provided by transplant centers participating in the Collaborative Transplant Study. RESULTS: HLA-C mismatch was found to be associated with significantly decreased graft survival in presensitized (P<0.001) but not in non-presensitized (P=0.75) recipients. Mismatch of certain HLA-C epitopes seemed to be more influential than others, with mismatches showing a negative impact on graft survival in presensitized patients. CONCLUSIONS: HLA-C mismatch has a substantial deleterious effect on graft survival in presensitized kidney recipients. Our study points out the need for investigations directed at identifying donor-specific HLA-C antibodies and evaluating their relevance in transplantation. In view of the fact that current assays for determining HLA-C specific antibodies are hampered by additional detection of clinically irrelevant antibodies, matching for HLA-C may provide a reasonable approach to improve transplant outcomes in presensitized kidney transplant recipients. |
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| DOI: | doi:10.1097/TP.0b013e318224c14e |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1097/TP.0b013e318224c14e |
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| | Volltext: https://journals.lww.com/transplantjournal/Fulltext/2011/08270/Deleterious_Impact_of_Mismatching_for_Human.7.aspx |
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| | DOI: https://doi.org/10.1097/TP.0b013e318224c14e |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Cadaver |
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| | Epitopes |
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| | Female |
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| | Graft Survival |
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| | Histocompatibility Testing |
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| | HLA-A Antigens |
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| | HLA-B Antigens |
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| | HLA-C Antigens |
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| | Humans |
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| | Isoantibodies |
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| | Kidney Transplantation |
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| | Linkage Disequilibrium |
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| | Male |
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| | Middle Aged |
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| | Time Factors |
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| | Tissue Donors |
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| K10plus-PPN: | 1759436372 |
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| Verknüpfungen: | → Zeitschrift |
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Deleterious impact of mismatching for human leukocyte antigen-C in presensitized recipients of kidney transplants / Tran, Thuong Hien [VerfasserIn]; 2011 (Online-Ressource)
