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Status: Bibliographieeintrag

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Verfasst von:Süsal, Caner [VerfasserIn]   i
 Ovens, Jörg [VerfasserIn]   i
 Mahmoud, Khaled [VerfasserIn]   i
 Döhler, Bernd [VerfasserIn]   i
 Scherer, Sabine [VerfasserIn]   i
 Ruhenstroth, Andrea [VerfasserIn]   i
 Tran, Thuong Hien [VerfasserIn]   i
 Heinold, Andreas [VerfasserIn]   i
 Opelz, Gerhard [VerfasserIn]   i
Titel:No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-antigen testing
Titelzusatz:a Collaborative Transplant Study report
Verf.angabe:Caner Süsal, Jörg Ovens, Khaled Mahmoud, Bernd Döhler, Sabine Scherer, Andrea Ruhenstroth, Thuong Hien Tran, Andreas Heinold, Gerhard Opelz
Jahr:2011
Umfang:5 S.
Teil:volume:91
 year:2011
 number:8
 pages:883-887
 extent:5
Fussnoten:Gesehen am 02.06.2021
Titel Quelle:Enthalten in: Transplantation
Ort Quelle:Hagerstown, Md. : Lippincott Williams & Wilkins, 1963
Jahr Quelle:2011
Band/Heft Quelle:91(2011), 8, Seite 883-887
ISSN Quelle:1534-6080
Abstract:BACKGROUND: It is unclear whether kidney transplant recipients with preformed donor-specific human leukocyte antigen (HLA) antibodies (DSA) detectable only in the highly sensitive Luminex single-antigen (LSA) assay are at an increased risk of graft failure. METHODS: We studied 3148 patients who received a deceased donor kidney graft between 1996 and 2008 and were enrolled in the prospective serum project of the Collaborative Transplant Study. There were 118 patients with graft loss during the first 3 years after transplantation on whom recipient and donor DNA was available for complete HLA typing. We compared the incidence of LSA-detected DSA in these patients with graft failure and matched controls with functioning grafts. All patients were found negative in the less-sensitive complement-dependent lymphocytotoxicity and enzyme-linked immunosorbent assays. RESULTS: When mean fluorescence intensity (MFI) of greater than or equal to 1000 was used as a cutoff for Luminex positivity, 118 patients with graft loss did not show a higher incidence of DSA against HLA-A, -B, -C, -DRB1/3/4/5, -DQA1, -DQB1, -DPA1, or -DPB1 antigens than 118 matched controls without graft loss (for all loci P not significant). The incidence of strong DSA (MFI ≥2000 or MFI ≥3000) detected only by LSA was low (for all loci between 0% and 5%) and did not identify unacceptable antigens that were relevant for graft loss within the first 3 years after transplantation. CONCLUSION: We conclude that, given currently practiced crossmatch procedures and immunosuppressive regimens, exclusion of donor organs carrying "unacceptable" HLA based exclusively on sensitive LSA antibody testing is not justified.
DOI:doi:10.1097/TP.0b013e3182100f77
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1097/TP.0b013e3182100f77
 Volltext: https://journals.lww.com/transplantjournal/Fulltext/2011/04270/No_Association_of_Kidney_Graft_Loss_With_Human.14.aspx
 DOI: https://doi.org/10.1097/TP.0b013e3182100f77
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Antibodies
 Case-Control Studies
 Enzyme-Linked Immunosorbent Assay
 Female
 Germany
 Graft Rejection
 Graft Survival
 Histocompatibility Testing
 HLA Antigens
 Humans
 Immunosuppressive Agents
 Kidney Transplantation
 Male
 Middle Aged
 Predictive Value of Tests
 Retrospective Studies
 Sensitivity and Specificity
 Treatment Outcome
K10plus-PPN:1759448141
Verknüpfungen:→ Zeitschrift

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