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Verfasst von:Grosskinsky, Sonja [VerfasserIn]   i
 Schott, Melanie [VerfasserIn]   i
 Brenner, Christiane [VerfasserIn]   i
 Cutler, Sally J. [VerfasserIn]   i
 Simon, Markus M. [VerfasserIn]   i
 Wallich, Reinhard [VerfasserIn]   i
Titel:Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis
Verf.angabe:Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J. Cutler, Markus M. Simon, Reinhard Wallich
E-Jahr:2010
Jahr:June 1, 2010
Umfang:12 S.
Teil:volume:4
 year:2010
 number:6
 elocationid:e698
 pages:1-12
 extent:12
Fussnoten:Gesehen am 07.06.2021
Titel Quelle:Enthalten in: Public Library of SciencePLoS neglected tropical diseases
Ort Quelle:Lawrence, Kan. : PLoS, 2007
Jahr Quelle:2010
Band/Heft Quelle:4(2010), 6, Artikel-ID e698, Seite 1-12
ISSN Quelle:1935-2735
Abstract:The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B. recurrentis surface receptor, HcpA, specifically binds factor H, the regulator of the alternative pathway of complement activation, thereby inhibiting complement mediated bacteriolysis. Here, we show that B. recurrentis spirochetes express another potential outer membrane lipoprotein, termed CihC, and acquire C4b-binding protein (C4bp) and human C1 esterase inhibitor (C1-Inh), the major inhibitors of the classical and lectin pathway of complement activation. A highly homologous receptor for C4bp was also found in the African tick-borne relapsing fever spirochete B. duttonii. Upon its binding to B. recurrentis or recombinant CihC, C4bp retains its functional potential, i.e. facilitating the factor I-mediated degradation of C4b. The additional finding that ectopic expression of CihC in serum sensitive B. burgdorferi significantly increased spirochetal resistance against human complement suggests this receptor to substantially contribute, together with other known strategies, to immune evasion of B. recurrentis.
DOI:doi:10.1371/journal.pntd.0000698
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1371/journal.pntd.0000698
 DOI: https://doi.org/10.1371/journal.pntd.0000698
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amino Acid Sequence
 Bacterial Outer Membrane Proteins
 Binding Sites
 Borrelia
 Cell Death
 Cloning, Molecular
 Coenzymes
 Complement C1 Inhibitor Protein
 Complement C4b-Binding Protein
 Electrophoresis, Gel, Pulsed-Field
 Flow Cytometry
 Histocompatibility Antigens
 Humans
 Molecular Sequence Data
 Protein Binding
 Sequence Alignment
 Surface Properties
K10plus-PPN:1759891835
Verknüpfungen:→ Zeitschrift

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