| |  Online-Ressource |
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| Verfasst von: | Grosskinsky, Sonja [VerfasserIn]  |
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| | Schott, Melanie [VerfasserIn] |
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| | Brenner, Christiane [VerfasserIn] |
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| | Cutler, Sally J. [VerfasserIn] |
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| | Kraiczy, Peter [VerfasserIn] |
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| | Zipfel, Peter F. [VerfasserIn] |
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| | Simon, Markus M. [VerfasserIn] |
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| | Wallich, Reinhard [VerfasserIn] |
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| Titel: | Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity |
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| Verf.angabe: | Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J. Cutler, Peter Kraiczy, Peter F. Zipfel, Markus M. Simon, Reinhard Wallich |
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| E-Jahr: | 2009 |
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| Jahr: | March 24, 2009 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 07.06.2021 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2009 |
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| Band/Heft Quelle: | 4(2009), 3, Artikel-ID e4858, Seite 1-12 |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates. Here we identify for the first time a multifunctional surface lipoprotein of B. recurrentis, termed HcpA, and demonstrate that it binds human complement regulators, Factor H, CFHR-1, and simultaneously, the host protease plasminogen. Cell surface bound factor H was found to retain its activity and to confer resistance to complement attack. Moreover, ectopic expression of HcpA in a B. burgdorferi B313 strain, deficient in Factor H binding proteins, protected the transformed spirochetes from complement-mediated killing. Furthermore, HcpA-bound plasminogen/plasmin endows B. recurrentis with the potential to resist opsonization and to degrade extracellular matrix components. Together, the present study underscores the high virulence potential of B. recurrentis. The elucidation of the molecular basis underlying the versatile strategies of B. recurrentis to escape innate immunity and to persist in human tissues, including the brain, may help to understand the pathological processes underlying louse-borne relapsing fever. |
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| DOI: | doi:10.1371/journal.pone.0004858 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://dx.doi.org/10.1371/journal.pone.0004858 |
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| | Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004858 |
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| | DOI: https://doi.org/10.1371/journal.pone.0004858 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bacterial Proteins |
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| | Borrelia |
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| | Complement C3b Inactivator Proteins |
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| | Complement Factor H |
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| | Complement System Proteins |
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| | Extracellular Matrix |
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| | Humans |
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| | Immunity, Innate |
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| | Opsonin Proteins |
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| | Plasminogen |
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| | Protein Binding |
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| K10plus-PPN: | 1759903523 |
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| Verknüpfungen: | → Zeitschrift |
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Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity / Grosskinsky, Sonja [VerfasserIn]; March 24, 2009 (Online-Ressource)
