| |  Online-Ressource |
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| Verfasst von: | Sonnek, Benedikt [VerfasserIn]  |
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| | Driedger, Jan Henje [VerfasserIn] |
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| | Mütze, Ulrike [VerfasserIn] |
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| | Schubert-Bast, Susanne [VerfasserIn] |
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| | Bast, Thomas [VerfasserIn] |
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| | Balke, Doreen [VerfasserIn] |
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| | Reuner, Gitta [VerfasserIn] |
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| | Schuler, Elisabeth [VerfasserIn] |
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| | Klabunde-Cherwon, Annick [VerfasserIn] |
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| | Hoffmann, Georg F. [VerfasserIn] |
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| | Kölker, Stefan [VerfasserIn] |
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| | Syrbe, Steffen [VerfasserIn] |
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| Titel: | Clinical spectrum and treatment outcome of 95 children with continuous spikes and waves during sleep (CSWS) |
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| Verf.angabe: | Benedikt Sonnek, Jan Henje Döring, Ulrike Mütze, Susanne Schubert-Bast, Thomas Bast, Doreen Balke, Gitta Reuner, Elisabeth Schuler, Annick Klabunde-Cherwon, Georg F. Hoffmann, Stefan Kölker, Steffen Syrbe |
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| Jahr: | 2021 |
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| Umfang: | 7 S. |
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| Fussnoten: | Online 24 October 2020 ; Gesehen am 08.06.2021 |
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| Titel Quelle: | Enthalten in: European journal of paediatric neurology |
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| Ort Quelle: | Burlington, Mass. : Harcourt, 1997 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 30(2021), Seite 121-127 |
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| ISSN Quelle: | 1532-2130 |
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| Abstract: | Objective - Continuous spikes and waves during sleep (CSWS) is an epileptic encephalopathy characterized by generalised epileptiform activity and neurocognitive dysfunction. Causes and outcome are diverse and treatment is mainly empirical. - Methods - Retrospective descriptive analysis of clinical and EEG data of children with CSWS diagnosed between 1998 and 2018 at the University Hospital Heidelberg. - Results - Ninety-five children were included with a median age at diagnosis of 5.4 years. A structural/metabolic aetiology was found in 43.2%, genetic alterations in 17.9%, while it remained unknown in 38.9%. The proportion of patients with genetic aetiology increased from 10.3% (1998-2007) to 22.8% (2008-2018). On average, each patient received 5 different treatments. CSWS was refractory in >70% of cases, steroids and neurosurgery were most effective. No difference was observed between children with CSWS or Near-CSWS (Spike-Wave-Index 40-85%). - Conclusions - Our cohort confirms CSWS as an age-dependent epileptic encephalopathy. Structural brain abnormalities were most frequent, but genetic causes are increasingly identified. More specific criteria for the diagnosis and treatment goals should be elaborated and implemented based on evidence. - Significance - This study is the largest monocentric observational study on treatment effects in children with CSWS, providing data for diagnostic and therapeutic decisions. |
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| DOI: | doi:10.1016/j.ejpn.2020.10.010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ejpn.2020.10.010 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1090379820302038 |
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| | DOI: https://doi.org/10.1016/j.ejpn.2020.10.010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Continuous spikes and waves during sleep |
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| | CSWS |
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| | Electrical status epilepticus during slow sleep |
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| | Epilepsy |
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| | Epileptic encephalopathy |
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| | ESES |
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| K10plus-PPN: | 176002094X |
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| Verknüpfungen: | → Zeitschrift |
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Clinical spectrum and treatment outcome of 95 children with continuous spikes and waves during sleep (CSWS) / Sonnek, Benedikt [VerfasserIn]; 2021 (Online-Ressource)
