Preclinical in vivo modeling of pediatric sarcoma

• Verfasst von: Imle, Roland [VerfasserIn]
• Verfasst von: Kommoss, Felix [VerfasserIn]
• Verfasst von: Banito, Ana [VerfasserIn]
• Titel: Preclinical in vivo modeling of pediatric sarcoma
• Titelzusatz: promises and limitations
• Verf.angabe: Roland Imle, Felix K.F. Kommoss, and Ana Banito
• E-Jahr: 2021
• Jahr: 8 April 2021
• Umfang: 27 S.
• Fussnoten: Gesehen am 09.06.2021
• Titel Quelle: Enthalten in: Journal of Clinical Medicine
• Ort Quelle: Basel : MDPI, 2012
• Jahr Quelle: 2021
• Band/Heft Quelle: 10(2021), 8, Artikel-ID 1578, Seite 1-27
• ISSN Quelle: 2077-0383
• DOI: doi:10.3390/jcm10081578
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: animal models
• Sach-SW: GEMMs
• Sach-SW: PDXs
• Sach-SW: pediatric sarcoma
• Sach-SW: preclinical testing
• K10plus-PPN: 1760101966

Abstract

Pediatric sarcomas are an extremely heterogeneous group of genetically distinct diseases. Despite the increasing knowledge on their molecular makeup in recent years, true therapeutic advancements are largely lacking and prognosis often remains dim, particularly for relapsed and metastasized patients. Since this is largely due to the lack of suitable model systems as a prerequisite to develop and assess novel therapeutics, we here review the available approaches to model sarcoma in vivo. We focused on genetically engineered and patient-derived mouse models, compared strengths and weaknesses, and finally explored possibilities and limitations to utilize these models to advance both biological understanding as well as clinical diagnosis and therapy.