| |  Online-Ressource |
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| Verfasst von: | Thiele, Kirsten [VerfasserIn]  |
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| | Bierhaus, Angelika [VerfasserIn] |
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| | Autschbach, Frank [VerfasserIn] |
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| | Hofmann Bowman, Marion [VerfasserIn] |
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| | Stremmel, Wolfgang [VerfasserIn] |
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| | Thiele, Hanshelmut [VerfasserIn] |
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| | Ziegler, Reinhard [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| Titel: | Cell specific effects of glucocorticoid treatment on the NF-κBp65/IκBα system in patients with Crohn’s disease |
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| Verf.angabe: | K. Thiele, A. Bierhaus, F. Autschbach, M. Hofmann, W. Stremmel, H. Thiele, R. Ziegler, P.P. Nawroth |
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| E-Jahr: | 1999 |
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| Jahr: | November 1, 1999 |
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| Fussnoten: | Gesehen am 09.06.2021 |
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| Titel Quelle: | Enthalten in: Gut |
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| Ort Quelle: | London : BMJ Publishing Group, 1960 |
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| Jahr Quelle: | 1999 |
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| Band/Heft Quelle: | 45(1999), 5, Seite 693-704 |
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| ISSN Quelle: | 1468-3288 |
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| Abstract: | Glucocorticoid treatment is known to reduce nuclear factor-kappa B (NF-κB)p65 binding activity and activation in lamina propria cells of patients with Crohn’s disease. However, lamina propria cells of glucocorticoid treated patients did not show increased expression of IκBα, and the hypothesised upregulation of IκBα by glucocorticoid treatment has not yet been shown in vivo. To investigate whether cells other than lamina propria localised mononuclear cells contribute to increased IκBα, resection gut specimens from patients matched for Crohn’s disease activity index (CDAI) with or without glucocorticoid treatment were studied, and changes in the NF-κB/IκBα system were determined in the lamina propria as well as in underlying submucosal and endothelial cells. |
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| DOI: | doi:10.1136/gut.45.5.693 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1136/gut.45.5.693 |
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| | Volltext: https://gut.bmj.com/content/45/5/693 |
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| | DOI: https://doi.org/10.1136/gut.45.5.693 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CDAI |
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| | Crohn’s disease |
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| | inflammation |
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| | IκBα |
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| | NF-κBp65 |
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| | transcription factor |
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| K10plus-PPN: | 1760108294 |
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| Verknüpfungen: | → Zeitschrift |
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Cell specific effects of glucocorticoid treatment on the NF-κBp65/IκBα system in patients with Crohn’s disease / Thiele, Kirsten [VerfasserIn]; November 1, 1999 (Online-Ressource)
