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Verfasst von:Gerchen, Martin Fungisai [VerfasserIn]   i
 Weiss, Franziska [VerfasserIn]   i
 Kirsch, Martina [VerfasserIn]   i
 Rentsch, Alena [VerfasserIn]   i
 Halli, Patrick [VerfasserIn]   i
 Kiefer, Falk [VerfasserIn]   i
 Kirsch, Peter [VerfasserIn]   i
Titel:Dynamic frontostriatal functional peak connectivity (in alcohol use disorder)
Verf.angabe:Martin Fungisai Gerchen, Franziska Weiss, Martina Kirsch, Alena Rentsch, Patrick Halli, Falk Kiefer, Peter Kirsch
E-Jahr:2021
Jahr:January 2021
Umfang:11 S.
Fussnoten:Gesehen am 09.06.2021
Titel Quelle:Enthalten in: Human brain mapping
Ort Quelle:New York, NY : Wiley-Liss, 1993
Jahr Quelle:2021
Band/Heft Quelle:42(2021), 1 vom: Jan., Seite 36-46
ISSN Quelle:1097-0193
Abstract:Alcohol use disorder (AUD) is associated with changes in frontostriatal connectivity, but functional magnetic resonance imaging (fMRI) functional connectivity (FC) approaches are usually not adapted to these circuits. We developed a circuit-specific fMRI analysis approach to detect dynamic changes in frontostriatal FC inspired by medial-ventral-rostral to lateral-dorsal-caudal frontostriatal gradients originally identified in nonhuman primate tract-tracing data. In our PeaCoG (“peak connectivity on a gradient”) approach we use information about the location of strongest FC on empirical frontostriatal connectivity gradients. We have recently described a basic PeaCoG version with conventional FC, and now developed a dynamic PeaCoG approach with sliding-window FC. In resting state data of n = 66 AUD participants and n = 40 healthy controls we continue here the analyses that we began with the basic version. Our former result of an AUD-associated ventral shift in right orbitofrontal cortex PeaCoG is consistently detected in the dynamic approach. Temporospatial variability of dynamic PeaCoG in the left dorsolateral prefrontal cortex is reduced in AUD and associated with self-efficacy to abstain and days of abstinence. Our method has the potential to provide insight into the dynamics of frontostriatal circuits, which has so far been relatively unexplored, and into their role in mental disorders and normal cognition.
DOI:doi:10.1002/hbm.25201
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/hbm.25201
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.25201
 DOI: https://doi.org/10.1002/hbm.25201
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:alcohol addiction
 dorsolateral prefrontal cortex
 dynamic functional connectivity
 functional magnetic resonance imaging
 striatum
K10plus-PPN:1760114731
Verknüpfungen:→ Zeitschrift

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