Autofluorescence-guided surgery for the treatment of medication-related osteonecrosis of the jaw (MRONJ)

• Verfasst von: Otto, Sven [VerfasserIn]
• Verfasst von: Schnödt, Eva Maria [VerfasserIn]
• Verfasst von: Haidari, Selgai [VerfasserIn]
• Verfasst von: Brunner, Teresa Franziska [VerfasserIn]
• Verfasst von: Aljohani, Suad [VerfasserIn]
• Verfasst von: Mosleh, Mohamed [VerfasserIn]
• Verfasst von: Ristow, Oliver [VerfasserIn]
• Verfasst von: Tröltzsch, Matthias [VerfasserIn]
• Verfasst von: Pautke, Christoph [VerfasserIn]
• Verfasst von: Ehrenfeld, Michael [VerfasserIn]
• Verfasst von: Fliefel, Riham [VerfasserIn]
• Titel: Autofluorescence-guided surgery for the treatment of medication-related osteonecrosis of the jaw (MRONJ)
• Titelzusatz: a retrospective single-center study
• Verf.angabe: Sven Otto, Eva Maria Schnödt, Selgai Haidari, Teresa Franziska Brunner, Suad Aljohani, Mohamed Mosleh, Oliver Ristow, Matthias Troeltzsch, Christoph Pautke, Michael Ehrenfeld and Riham Fliefel
• Jahr: 2021
• Umfang: 8 S.
• Fussnoten: Online 26 October 2020 ; Gesehen am 14.06.2021
• Titel Quelle: Enthalten in: Oral surgery, oral medicine, oral pathology and oral radiology
• Ort Quelle: Orlando, Fla. [u.a.] : Elsevier, 2012
• Jahr Quelle: 2021
• Band/Heft Quelle: 131(2021), 5, Seite 519-526
• ISSN Quelle: 2212-4411
• DOI: doi:10.1016/j.oooo.2020.10.018
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1760365831

Abstract

Objective - Medication-related osteonecrosis of the jaw (MRONJ) has become a serious concern for patients under antiresorptive treatment, especially in the oncological setting. Different approaches have been described in the management of MRONJ, including innovative autofluorescence-guided surgery. However, until now, there has been a lack of data regarding the outcome. In this study, we evaluated the efficacy of minimally invasive autofluorescence-guided resection in MRONJ. - Study Design - Seventy-five patients with 82 lesions were included in this retrospective, single-center study. All included patients were diagnosed with MRONJ according to the American Association of Oral and Maxillofacial Surgeons guidelines and underwent autofluorescence-guided surgery with a minimum follow-up of 3 months. The primary outcome was complete integrity of the mucosa and absence of bone exposure. - Results - The MRONJ stages were stage 0 (3.7%), stage 1 (3.7%), stage 2 (75.6%), and stage 3 (17%). Overall, complete mucosal healing of all lesions after the first surgery was 81.7% (67 of 82), whereas it was 90.2% (74 of 82) after revision surgery. - Conclusions - The study showed that autofluorescence-guided surgery is a safe and successful treatment option that can be considered for all stages of MRONJ.