| |  Online-Ressource |
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| Verfasst von: | Sido, Bernd [VerfasserIn]  |
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| | Giese, Thomas [VerfasserIn] |
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| | Autschbach, Frank [VerfasserIn] |
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| | Lasitschka, Felix [VerfasserIn] |
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| | Schröder-Braunstein, Jutta [VerfasserIn] |
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| | Meuer, Stefan [VerfasserIn] |
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| Titel: | Potential role of thioredoxin in immune responses in intestinal lamina propria T lymphocytes |
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| Verf.angabe: | Bernd Sido, Thomas Giese, Frank Autschbach, Felix Lasitschka, Jutta Braunstein and Stefan C. Meuer |
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| E-Jahr: | 2005 |
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| Jahr: | 28 January 2005 |
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| Umfang: | 10 S. |
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| Teil: | volume:35 |
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| | year:2005 |
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| | number:2 |
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| | pages:408-417 |
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| | extent:10 |
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| Fussnoten: | Gesehen am 14.06.2021 |
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| Titel Quelle: | Enthalten in: European journal of immunology |
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| Ort Quelle: | Weinheim : Wiley-VCH, 1971 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 35(2005), 2, Seite 408-417 |
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| ISSN Quelle: | 1521-4141 |
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| Abstract: | Thioredoxin (TRX) is a ubiquitous oxidoreductase with strong co-cytokine, chemoattractant and anti-apoptotic activities. TRX expression was found to be particularly elevated in the intestinal mucosa, where its physiologic function is entirely unknown. Here, we demonstrate a high level of TRX expression in lamina propria T cells (LP-T) as opposed to autologous peripheral blood T lymphocytes (PB-T). Addition of recombinant human TRX (rhTRX) to PB-T enhances TRX gene expression. This autoregulation involves the calcineurin signaling pathway, as rhTRX antagonizes the cyclosporine A (CsA)- and tacrolimus-mediated suppression of TRX gene expression. Similarly, rhTRX reverses the suppression of IL-2 mRNA production by CsA and enhances cytokine production preferentially in prestimulated cells. The differential TRX expression in LP-T versus PB-T may thus contribute to the high-level, CsA-resistant IL-2 production characteristic for CD2-stimulated LP-T. Inversely, inactivation of TRX in LP-T through inhibition of TRX reductase abolishes cytokine gene expression. TRX may play a key role in the specialized intestinal microenvironment in amplifying immediate immune responses of LP-T whenever appropriate costimulation of LP-T is provided. |
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| DOI: | doi:10.1002/eji.200424500 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/eji.200424500 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.200424500 |
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| | DOI: https://doi.org/10.1002/eji.200424500 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cloning, Molecular |
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| | Colon |
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| | Cytokines |
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| | Humans |
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| | Immunity, Mucosal |
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| | Immunohistochemistry |
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| | Interleukin-2 |
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| | RNA, Messenger |
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| | T-Lymphocytes |
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| | Thioredoxin-Disulfide Reductase |
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| | Thioredoxins |
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| K10plus-PPN: | 1760378852 |
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| Verknüpfungen: | → Zeitschrift |
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Potential role of thioredoxin in immune responses in intestinal lamina propria T lymphocytes / Sido, Bernd [VerfasserIn]; 28 January 2005 (Online-Ressource)
