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| Verfasst von: | Türei, Dénes [VerfasserIn]  |
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| | Valdeolivas, Alberto [VerfasserIn] |
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| | Gul, Lejla [VerfasserIn] |
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| | Palacio-Escat, Nicolàs [VerfasserIn] |
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| | Klein, Michal [VerfasserIn] |
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| | Ivanova, Olga A. [VerfasserIn] |
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| | Ölbei, Márton [VerfasserIn] |
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| | Gabor, Attila [VerfasserIn] |
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| | Theis, Fabian [VerfasserIn] |
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| | Módos, Dezső [VerfasserIn] |
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| | Korcsmáros, Tamás [VerfasserIn] |
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| | Sáez Rodríguez, Julio [VerfasserIn] |
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| Titel: | Integrated intra- and intercellular signaling knowledge for multicellular omics analysis |
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| Verf.angabe: | Dénes Türei, Alberto Valdeolivas, Lejla Gul, Nicolàs Palacio-Escat, Michal Klein, Olga Ivanova, Márton Ölbei, Attila Gábor, Fabian Theis, Dezső Módos, Tamás Korcsmáros &Julio Saez-Rodriguez |
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| E-Jahr: | 2021 |
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| Jahr: | 22 March 2021 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 14.06.2021 |
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| Titel Quelle: | Enthalten in: Molecular systems biology |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2005 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 17(2021), 3, Artikel-ID e9923, Seite 1-16 |
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| ISSN Quelle: | 1744-4292 |
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| Abstract: | Abstract Molecular knowledge of biological processes is a cornerstone in omics data analysis. Applied to single-cell data, such analyses provide mechanistic insights into individual cells and their interactions. However, knowledge of intercellular communication is scarce, scattered across resources, and not linked to intracellular processes. To address this gap, we combined over 100 resources covering interactions and roles of proteins in inter- and intracellular signaling, as well as transcriptional and post-transcriptional regulation. We added protein complex information and annotations on function, localization, and role in diseases for each protein. The resource is available for human, and via homology translation for mouse and rat. The data are accessible via OmniPath?s web service (https://omnipathdb.org/), a Cytoscape plug-in, and packages in R/Bioconductor and Python, providing access options for computational and experimental scientists. We created workflows with tutorials to facilitate the analysis of cell?cell interactions and affected downstream intracellular signaling processes. OmniPath provides a single access point to knowledge spanning intra- and intercellular processes for data analysis, as we demonstrate in applications studying SARS-CoV-2 infection and ulcerative colitis. |
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| DOI: | doi:10.15252/msb.20209923 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.15252/msb.20209923 |
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| | kostenfrei: Volltext: https://www.embopress.org/doi/full/10.15252/msb.20209923 |
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| | DOI: https://doi.org/10.15252/msb.20209923 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | intercellular signaling |
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| | ligand-receptor interactions |
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| | omics integration |
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| | pathways |
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| | signaling network |
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| K10plus-PPN: | 176038240X |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Integrated intra- and intercellular signaling knowledge for multicellular omics analysis / Türei, Dénes [VerfasserIn]; 22 March 2021 (Online-Ressource)
