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Verfasst von:Schmidt, Carsten [VerfasserIn]   i
 Giese, Thomas [VerfasserIn]   i
 Hermann, Eva [VerfasserIn]   i
 Zeuzem, Stefan [VerfasserIn]   i
 Meuer, Stefan [VerfasserIn]   i
 Stallmach, Andreas [VerfasserIn]   i
Titel:Predictive value of mucosal TNF-alpha transcripts in steroid-refractory Crohn's disease patients receiving intensive immunosuppressive therapy
Verf.angabe:Carsten Schmidt, Thomas Giese, Eva Hermann, Stefan Zeuzem, Stefan C. Meuer, and Andreas Stallmach
Jahr:2007
Umfang:6 S.
Teil:volume:13
 year:2007
 number:1
 pages:65-70
 extent:6
Fussnoten:Gesehen am 16.06.2021
Titel Quelle:Enthalten in: Inflammatory bowel diseases
Ort Quelle:Oxford : Oxford University Press, 1995
Jahr Quelle:2007
Band/Heft Quelle:13(2007), 1, Seite 65-70
ISSN Quelle:1536-4844
Abstract:BACKGROUND: Concentrations of proinflammatory cytokines are increased in the intestinal mucosa of patients with active Crohn's disease (CD). In a prospective study we investigated whether cytokines can predict long-term remission (>6 months) in patients with steroid-refractory CD receiving treatment with infliximab or cyclophosphamide, followed by azathioprine or methotrexate. METHODS: Cytokine transcripts were quantified using real-time polymerase chain reaction (PCR) in mucosal biopsies from 19 patients with active, steroid-refractory CD before and 8 weeks after initiation of therapy. Patients were treated with cyclophosphamide (monthly treatment of 750 mg cyclophosphamide intravenously) or infliximab (5 mg/kg body weight) and were followed until relapse of the disease. Statistical analysis was performed to identify predictive factors to discriminate between patients with or without long-term remission. RESULTS: Seventeen out of 19 patients achieved remission of the disease, two patients were nonresponders, while six out of 17 patients exhibited an early recurrence. Pretreatment TNF-alpha, IL-18, MRP-14, and IL-8 transcripts were significantly correlated with long-term remission. While several cytokines, most importantly MMP-1, determined after 8 weeks were able to predict patients achieving long-term remission, only a decrease of TNF-alpha levels after 8 weeks was predictive. Overall, statistical analysis identified lower pretreatment TNF-alpha levels as the strongest predictor of long-term remission among baseline variables. CONCLUSIONS: Quantification of mucosal TNF-alpha transcripts prior to therapy allows identification of patients achieving long-term remission upon immunosuppression with infliximab or cyclophosphamide. Real-time PCR might have considerable potential in the analysis of disease activity and subsequent clinical management of patients with immunosuppressive therapies.
DOI:doi:10.1002/ibd.20012
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://dx.doi.org/10.1002/ibd.20012
 DOI: https://doi.org/10.1002/ibd.20012
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescent
 Adult
 Antibodies, Monoclonal
 Chemokines
 Crohn Disease
 Cyclophosphamide
 Cytokines
 Drug Resistance
 Female
 Gastrointestinal Agents
 Glucocorticoids
 Humans
 Immunosuppressive Agents
 Infliximab
 Intestinal Mucosa
 Male
 Middle Aged
 Prednisolone
 Remission Induction
 Tumor Necrosis Factor-alpha
K10plus-PPN:1760544183
Verknüpfungen:→ Zeitschrift

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