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Verfasst von:Ludolph, Albert C. [VerfasserIn]   i
 Dorst, Johannes [VerfasserIn]   i
 Dreyhaupt, Jens [VerfasserIn]   i
 Weishaupt, Jochen H. [VerfasserIn]   i
 Kassubek, Jan Rainer [VerfasserIn]   i
 Weiland, Ulrike [VerfasserIn]   i
 Meyer, Thomas [VerfasserIn]   i
 Petri, Susanne [VerfasserIn]   i
 Hermann, Andreas [VerfasserIn]   i
 Emmer, Alexander [VerfasserIn]   i
 Großkreutz, Julian [VerfasserIn]   i
 Grehl, Torsten [VerfasserIn]   i
 Zeller, Daniel [VerfasserIn]   i
 Boentert, Matthias [VerfasserIn]   i
 Schrank, Bertold [VerfasserIn]   i
 Prudlo, Johannes [VerfasserIn]   i
 Winkler, Andrea S. [VerfasserIn]   i
 Gorbulev, Stanislav [VerfasserIn]   i
 Roselli, Francesco [VerfasserIn]   i
 Schuster, Joachim [VerfasserIn]   i
 Dupuis, Luc [VerfasserIn]   i
Titel:Effect of high-caloric nutrition on survival in amyotrophic lateral sclerosis
Verf.angabe:Albert C. Ludolph, MD, Johannes Dorst, MD, Jens Dreyhaupt, PhD, Jochen H. Weishaupt, MD, Jan Kassubek, MD, Ulrike Weiland, MD, Thomas Meyer, MD, Susanne Petri, MD, Andreas Hermann, MD, PhD, Alexander Emmer, MD, Julian Grosskreutz, MD, Torsten Grehl, MD, Daniel Zeller, MD, Matthias Boentert, MD, Bertold Schrank, MD, Johannes Prudlo, MD, Andrea S. Winkler, MD, Stanislav Gorbulev, PhD, Francesco Roselli, MD, PhD, Joachim Schuster, PhD, and Luc Dupuis, PhD, for the LIPCAL-ALS Study Group
E-Jahr:2020
Jahr:February 2020
Umfang:11 S.
Teil:volume:87
 year:2020
 number:2
 month:02
 pages:206-216
 extent:11
Fussnoten:First published: 17 December 2019 ; Gesehen am 16.06.2021
Titel Quelle:Enthalten in: Annals of neurology
Ort Quelle:Hoboken, NJ : Wiley-Blackwell, 1977
Jahr Quelle:2020
Band/Heft Quelle:87(2020), 2 vom: Feb., Seite 206-216
ISSN Quelle:1531-8249
Abstract:Objective Weight loss has been identified as a negative prognostic factor in amyotrophic lateral sclerosis, but there is no evidence regarding whether a high-caloric diet increases survival. Therefore, we sought to evaluate the efficacy of a high-caloric fatty diet (HCFD) for increasing survival. Methods A 1:1 randomized, placebo-controlled, parallel-group, double-blinded trial (LIPCAL-ALS study) was conducted between February 2015 and September 2018. Patients were followed up at 3, 6, 9, 12, 15, and 18 months after randomization. The study was performed at 12 sites of the clinical and scientific network of German motor neuron disease centers (ALS/MND-NET). Eligible patients were randomly assigned (1:1) to receive either HCFD (405kcal/day, 100% fat) or placebo in addition to riluzole (100mg/day). The primary endpoint was survival time, defined as time to death or time to study cutoff date. Results Two hundred one patients (80 female, 121 male, age = 62.4 ± 10.8 years) were included. The confirmatory analysis of the primary outcome survival showed a survival probability of 0.39 (95% confidence interval [CI] = 0.27-0.51) in the placebo group and 0.37 (95% CI = 0.25-0.49) in the HCFD group, both after 28 months (point in time of the last event). The hazard ratio was 0.97, 1-sided 97.5% CI = −∞ to 1.44, p = 0.44. Interpretation The results provide no evidence for a life-prolonging effect of HCFD for the whole amyotrophic lateral sclerosis population. However, post hoc analysis revealed a significant survival benefit for the subgroup of fast-progressing patients. ANN NEUROL 2020;87:206-216
DOI:doi:10.1002/ana.25661
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/ana.25661
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25661
 DOI: https://doi.org/10.1002/ana.25661
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1760576875
Verknüpfungen:→ Zeitschrift

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