| |  Online-Ressource |
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| Verfasst von: | Verde, Federico [VerfasserIn]  |
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| | Steinacker, Petra [VerfasserIn] |
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| | Weishaupt, Jochen H. [VerfasserIn] |
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| | Kassubek, Jan [VerfasserIn] |
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| | Oeckl, Patrick [VerfasserIn] |
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| | Halbgebauer, Steffen [VerfasserIn] |
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| | Tumani, Hayrettin [VerfasserIn] |
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| | Arnim, Christine A. F. von [VerfasserIn] |
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| | Dorst, Johannes [VerfasserIn] |
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| | Feneberg, Emily [VerfasserIn] |
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| | Mayer, Benjamin [VerfasserIn] |
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| | Müller, Hans-Peter [VerfasserIn] |
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| | Gorges, Martin [VerfasserIn] |
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| | Rosenbohm, Angela [VerfasserIn] |
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| | Volk, Alexander E. [VerfasserIn] |
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| | Silani, Vincenzo [VerfasserIn] |
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| | Ludolph, Albert C. [VerfasserIn] |
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| | Otto, Markus [VerfasserIn] |
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| Titel: | Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis |
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| Verf.angabe: | Federico Verde, Petra Steinacker, Jochen H Weishaupt, Jan Kassubek, Patrick Oeckl, Steffen Halbgebauer, Hayrettin Tumani, Christine AF von Arnim, Johannes Dorst, Emily Feneberg, Benjamin Mayer, Hans-Peter Müller, Martin Gorges, Angela Rosenbohm, Alexander E Volk, Vincenzo Silani, Albert C Ludolph, Markus Otto |
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| Jahr: | 2019 |
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| Umfang: | 8 S. |
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| Fussnoten: | Published online first 11 October 2018 ; Gesehen am 16.06.2021 |
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| Titel Quelle: | Enthalten in: Journal of neurology, neurosurgery, and psychiatry |
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| Ort Quelle: | London : BMJ Publishing Group, 1944 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 90(2019), 2, Seite 157-164 |
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| ISSN Quelle: | 1468-330X |
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| Abstract: | <h3>Objective</h3> <p>To determine the diagnostic and prognostic performance of serum neurofilament light chain (NFL) in amyotrophic lateral sclerosis (ALS).</p><h3>Methods</h3> <p>This single-centre, prospective, longitudinal study included the following patients: 124 patients with ALS; 50 patients without neurodegenerative diseases; 44 patients with conditions included in the differential diagnosis of ALS (disease controls); 65 patients with other neurodegenerative diseases (20 with frontotemporal dementia, 20 with Alzheimer’s disease, 19 with Parkinson’s disease, 6 with Creutzfeldt-Jakob disease (CJD)). Serum NFL levels were measured using the ultrasensitive single molecule array (Simoa) technology.</p><h3>Results</h3> <p>Serum NFL levels were higher in ALS in comparison to all other categories except for CJD. A cut-off level of 62 pg/mL discriminated between ALS and all other conditions with 85.5% sensitivity (95% CI 78% to 91.2%) and 81.8% specificity (95% CI 74.9% to 87.4%). Among patients with ALS, serum NFL correlated positively with disease progression rate (r<sub>s</sub>=0.336, 95% CI 0.14 to 0.506, p=0.0008), and higher levels were associated with shorter survival (p=0.0054). Serum NFL did not differ among patients in different ALS pathological stages as evaluated by diffusion-tensor imaging, and in single patients NFL levels were stable over time.</p><h3>Conclusions</h3> <p>Serum NFL is increased in ALS in comparison to other conditions and can serve as diagnostic and prognostic biomarker. We established a cut-off level for the diagnosis of ALS.</p> |
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| DOI: | doi:10.1136/jnnp-2018-318704 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1136/jnnp-2018-318704 |
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| | Volltext: https://jnnp.bmj.com/content/90/2/157 |
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| | DOI: https://doi.org/10.1136/jnnp-2018-318704 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1760587184 |
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| Verknüpfungen: | → Zeitschrift |
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Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis / Verde, Federico [VerfasserIn]; 2019 (Online-Ressource)
