| |  Online-Ressource |
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| Verfasst von: | Hornuß, Daniel [VerfasserIn]  |
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| | Rudi, Anna [VerfasserIn] |
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| | Koerner, Lucas [VerfasserIn] |
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| | Mohr, Isabelle [VerfasserIn] |
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| | Merle, Uta [VerfasserIn] |
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| | Wehling, Cyrill [VerfasserIn] |
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| | Rupp, Christian [VerfasserIn] |
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| | Dill, Michael T. [VerfasserIn] |
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| | Golriz, Mohammad [VerfasserIn] |
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| | Schnitzler, Paul [VerfasserIn] |
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| | Brenner, Thorsten [VerfasserIn] |
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| | Mehrabi, Arianeb [VerfasserIn] |
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| | Weiss, Karl Heinz [VerfasserIn] |
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| | Mieth, Markus [VerfasserIn] |
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| Titel: | HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients |
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| Titelzusatz: | a retrospective study |
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| Verf.angabe: | Daniel Hornuss, Anna Rudi, Lucas Koerner, Isabelle Mohr, Uta Merle, Cyrill Wehling, Christian Rupp, Michael T. Dill, Mohammad Golriz, Paul Schnitzler, Thorsten Brenner, Arianeb Mehrabi, Karl Heinz Weiss, Markus Mieth |
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| E-Jahr: | 2021 |
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| Jahr: | 16 March 2021 |
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| Umfang: | 9 S. |
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| Fussnoten: | Im Titel steht ein Trema über dem "i" bei naïve ; Gesehen am 16.06.2021 |
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| Titel Quelle: | Enthalten in: Clinics and research in hepatology and gastroenterology |
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| Ort Quelle: | Amsterdam : Elsevier Masson, 2011 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 45(2021), 2, Artikel-ID 101496, Seite 1-9 |
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| ISSN Quelle: | 2210-741X |
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| Abstract: | Background - Anti-HBc only positive liver grafts may be suitable for HBV-naive recipients insofar as an appropriate infection prophylaxis is performed. Therefore, we investigated the effect of prophylactic regimens on HBV infection prevention and long-term outcome of anti-HBc-positive graft recipients. - Patients and methods - This retrospective monocenter study consisted of a cohort of 1912 patients who underwent deceased donor liver transplantation at our transplant center between June 1987 and July 2019. 81 HBV-naïve patients after reception of an anti-HBc-positive liver-graft and consecutive HBV prophylaxis were selected for further examination. HBV infection rate and host- and graft-survival rates were compared to a matched control group consisting of 162 HBV-naïve patients after reception of anti-HBc-negative grafts. Pharmaceutical HBV prophylaxis included: only HBIG, only NUCs, or combined HBIG and NUCs. - Results - Compared to control cases of HBV-naïve anti-HBc-negative graft recipients, no differences in host- and graft-survival rate were determined.13 of 81 anti-HBc-positive graft recipients (16%) developed HBV-infection after liver transplantation. No patient suffered from HBV infection after receiving modern NUCs. Survival analysis showed no statistical differences between patients with and without infection concerning host- and graft-survival. - Conclusion - Especially in times of organ shortage, anti-HBc-positive liver grafts may be useful for liver transplantation in HBV-naïve recipients. Efficient prophylactic regimens can prevent HBV-infection. |
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| DOI: | doi:10.1016/j.clinre.2020.07.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.clinre.2020.07.003 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2210740120301911 |
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| | DOI: https://doi.org/10.1016/j.clinre.2020.07.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | anti-HBc-positive liver-grafts |
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| | HBIG |
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| | HBV-infection |
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| | Hepatitis B |
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| | Liver transplantation |
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| | Nucleoside analogue |
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| | Nucleotide analogue |
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| K10plus-PPN: | 1760653098 |
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| Verknüpfungen: | → Zeitschrift |
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HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients / Hornuß, Daniel [VerfasserIn]; 16 March 2021 (Online-Ressource)
