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Verfasst von:Gülmez Karaca, Kübra [VerfasserIn]   i
 Brito, David V. C. [VerfasserIn]   i
 Kupke, Janina [VerfasserIn]   i
 Zeuch, Benjamin [VerfasserIn]   i
 Oliveira, Ana [VerfasserIn]   i
Titel:Engram reactivation during memory retrieval predicts long-term memory performance in aged mice
Verf.angabe:Kubra Gulmez Karaca, David V.C. Brito, Janina Kupke, Benjamin Zeuch, Ana M.M. Oliveira
E-Jahr:2021
Jahr:9 February 2021
Umfang:6 S.
Teil:volume:101
 year:2021
 month:05
 pages:256-261
 extent:6
Fussnoten:Gesehen am 17.06.2021
Titel Quelle:Enthalten in: Neurobiology of aging
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1980
Jahr Quelle:2021
Band/Heft Quelle:101(2021) vom: Mai, Seite 256-261
ISSN Quelle:1558-1497
Abstract:Age-related cognitive decline preferentially targets long-lasting episodic memories that require intact hippocampal function. Memory traces (or engrams) are believed to be encoded within the neurons activated during learning (neuronal ensembles), and recalled by reactivation of the same population. However, whether engram reactivation dictates memory performance late in life is not known. Here, we labeled neuronal ensembles formed during object location recognition learning in the dentate gyrus, and analyzed the reactivation of this population during long-term memory recall in young adult, cognitively impaired- and unimpaired-aged mice. We found that reactivation of memory-encoding neuronal ensembles at long-term memory recall was disrupted in impaired but not unimpaired-aged mice. Furthermore, we showed that the memory performance in the aged population correlated with the degree of engram reactivation at long-term memory recall. Overall, our data implicates recall-induced engram reactivation as a prediction factor of memory performance in aging. Moreover, our findings suggest impairments in neuronal ensemble stabilization and/or reactivation as an underlying mechanism in age-dependent cognitive decline.
DOI:doi:10.1016/j.neurobiolaging.2021.01.019
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.neurobiolaging.2021.01.019
 Volltext: https://www.sciencedirect.com/science/article/pii/S0197458021000269
 DOI: https://doi.org/10.1016/j.neurobiolaging.2021.01.019
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aging
 Dentate gyrus
 Hippocampus
 Memory trace
 Neuronal ensembles
 Object location memory
K10plus-PPN:1760700193
Verknüpfungen:→ Zeitschrift

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