Status: Bibliographieeintrag
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| Verfasst von: | Gülmez Karaca, Kübra [VerfasserIn]  |
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| | Brito, David V. C. [VerfasserIn] |
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| | Kupke, Janina [VerfasserIn] |
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| | Zeuch, Benjamin [VerfasserIn] |
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| | Oliveira, Ana [VerfasserIn] |
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| Titel: | Engram reactivation during memory retrieval predicts long-term memory performance in aged mice |
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| Verf.angabe: | Kubra Gulmez Karaca, David V.C. Brito, Janina Kupke, Benjamin Zeuch, Ana M.M. Oliveira |
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| E-Jahr: | 2021 |
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| Jahr: | 9 February 2021 |
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| Umfang: | 6 S. |
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| Teil: | volume:101 |
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| | year:2021 |
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| | month:05 |
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| | pages:256-261 |
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| | extent:6 |
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| Fussnoten: | Gesehen am 17.06.2021 |
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| Titel Quelle: | Enthalten in: Neurobiology of aging |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1980 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 101(2021) vom: Mai, Seite 256-261 |
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| ISSN Quelle: | 1558-1497 |
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| Abstract: | Age-related cognitive decline preferentially targets long-lasting episodic memories that require intact hippocampal function. Memory traces (or engrams) are believed to be encoded within the neurons activated during learning (neuronal ensembles), and recalled by reactivation of the same population. However, whether engram reactivation dictates memory performance late in life is not known. Here, we labeled neuronal ensembles formed during object location recognition learning in the dentate gyrus, and analyzed the reactivation of this population during long-term memory recall in young adult, cognitively impaired- and unimpaired-aged mice. We found that reactivation of memory-encoding neuronal ensembles at long-term memory recall was disrupted in impaired but not unimpaired-aged mice. Furthermore, we showed that the memory performance in the aged population correlated with the degree of engram reactivation at long-term memory recall. Overall, our data implicates recall-induced engram reactivation as a prediction factor of memory performance in aging. Moreover, our findings suggest impairments in neuronal ensemble stabilization and/or reactivation as an underlying mechanism in age-dependent cognitive decline. |
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| DOI: | doi:10.1016/j.neurobiolaging.2021.01.019 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.neurobiolaging.2021.01.019 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0197458021000269 |
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| | DOI: https://doi.org/10.1016/j.neurobiolaging.2021.01.019 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Aging |
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| | Dentate gyrus |
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| | Hippocampus |
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| | Memory trace |
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| | Neuronal ensembles |
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| | Object location memory |
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| K10plus-PPN: | 1760700193 |
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| Verknüpfungen: | → Zeitschrift |
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Engram reactivation during memory retrieval predicts long-term memory performance in aged mice / Gülmez Karaca, Kübra [VerfasserIn]; 9 February 2021 (Online-Ressource)
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