Signaling cascades of Pasteurella multocida toxin in immune evasion

• Verfasst von: Hieke-Kubatzky, Katharina [VerfasserIn]
• Verfasst von: Handrick, Bianca [VerfasserIn]
• Verfasst von: Hildebrand, Dagmar [VerfasserIn]
• Titel: Signaling cascades of Pasteurella multocida toxin in immune evasion
• Verf.angabe: Katharina F. Kubatzky, Bianca Kloos and Dagmar Hildebrand
• E-Jahr: 2013
• Jahr: 24 September 2013
• Umfang: 18 S.
• Fussnoten: Gesehen am 17.06.2021
• Titel Quelle: Enthalten in: Toxins
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2013
• Band/Heft Quelle: 5(2013), 9 vom: Sept., Seite 1664-1681
• ISSN Quelle: 2072-6651
• DOI: doi:10.3390/toxins5091664
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Pasteurella multocida
• Sach-SW: bacterial toxin
• Sach-SW: carcinogenesis
• Sach-SW: immune evasion
• Sach-SW: osteoclast
• Sach-SW: osteoimmunology
• Sach-SW: signal transduction
• K10plus-PPN: 1760710962

Abstract

Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host’s immune system are just beginning to unravel.