Status: Bibliographieeintrag
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| Verfasst von: | Emlen, Woodruff [VerfasserIn]  |
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| | Li, Wenhan [VerfasserIn] |
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| | Kirschfink, Michael [VerfasserIn] |
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| Titel: | Therapeutic complement inhibition |
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| Titelzusatz: | new developments |
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| Verf.angabe: | Woodruff Emlen, Wenhan Li, and Michael Kirschfink |
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| Jahr: | 2010 |
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| Umfang: | 9 S. |
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| Teil: | volume:36 |
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| | year:2010 |
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| | number:6 |
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| | pages:660-668 |
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| | extent:9 |
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| Fussnoten: | Gesehen am 18.06.2021 |
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| Titel Quelle: | Enthalten in: Seminars in thrombosis and hemostasis |
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| Ort Quelle: | New York, NY : Thieme, 1974 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 36(2010), 6, Seite 660-668 |
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| ISSN Quelle: | 1098-9064 |
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| Abstract: | Activation of the complement system significantly contributes to the pathogenesis of various acute and chronic inflammatory diseases. Current strategies to inhibit complement include the replacement or substitution of endogenous soluble complement inhibitors (e.g., C1 inhibitor [C1 inh], recombinant soluble complement receptor 1, TP10), the administration of antibodies to block key proteins of the cascade reaction (e.g., C5) or to neutralize the action of the complement-derived anaphylatoxins, or blockade of complement receptors (e.g., C5aR, CD88). The recent approvals of anti-C5 for the treatment of paroxysmal nocturnal hemoglobinuria as well as of C1 inh for the treatment of hereditary angioedema beyond European countries have provided a resurgence of interest in the potential of complement therapeutics for the treatment of disease. |
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| DOI: | doi:10.1055/s-0030-1262888 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1055/s-0030-1262888 |
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| | Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0030-1262888 |
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| | DOI: https://doi.org/10.1055/s-0030-1262888 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Angioedemas, Hereditary |
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| | Animals |
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| | Antibodies, Monoclonal |
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| | Complement Activation |
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| | Complement C1 Inhibitor Protein |
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| | Complement Pathway, Alternative |
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| | Complement System Proteins |
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| | Humans |
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| K10plus-PPN: | 1760793000 |
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| Verknüpfungen: | → Zeitschrift |
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Therapeutic complement inhibition / Emlen, Woodruff [VerfasserIn]; 2010 (Online-Ressource)
68750412
