| |  Online-Ressource |
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| Verfasst von: | Heo, Gyu Seong [VerfasserIn]  |
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| | Bajpai, Geetika [VerfasserIn] |
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| | Li, Wenjun [VerfasserIn] |
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| | Luehmann, Hannah P. [VerfasserIn] |
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| | Sultan, Deborah H. [VerfasserIn] |
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| | Dun, Hao [VerfasserIn] |
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| | Leuschner, Florian [VerfasserIn] |
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| | Brody, Steven L. [VerfasserIn] |
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| | Gropler, Robert J. [VerfasserIn] |
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| | Kreisel, Daniel [VerfasserIn] |
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| | Lavine, Kory J. [VerfasserIn] |
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| | Liu, Yongjian [VerfasserIn] |
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| Titel: | Targeted PET imaging of chemokine receptor 2-positive monocytes and macrophages in the injured heart |
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| Verf.angabe: | Gyu Seong Heo, Geetika Bajpai, Wenjun Li, Hannah P. Luehmann, Deborah H. Sultan, Hao Dun, Florian Leuschner, Steven L. Brody, Robert J. Gropler, Daniel Kreisel, Kory J. Lavine, Yongjian Liu |
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| E-Jahr: | 2021 |
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| Jahr: | May 22, 2020 |
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| Umfang: | 4 S. |
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| Teil: | volume:62 |
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| | year:2021 |
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| | number:1 |
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| | pages:111-114 |
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| | extent:4 |
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| Fussnoten: | Gesehen am 22.06.2021 |
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| Titel Quelle: | Enthalten in: Journal of nuclear medicine |
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| Ort Quelle: | New York, NY : Soc., 1964 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 62(2021), 1, Seite 111-114 |
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| ISSN Quelle: | 2159-662X |
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| | 1535-5667 |
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| Abstract: | Proinflammatory macrophages are important mediators of inflammation after myocardial infarction and of allograft injury after heart transplantation. The aim of this study was to image the recruitment of proinflammatory chemokine receptor 2-positive (CCR2+) cells in multiple heart injury models. Methods: 64 Cu-DOTA-extracellular loop 1 inverso (ECL1i) PET was used to image CCR2+ monocytes and macrophages in a heart transplantation mouse model. Flow cytometry was performed to characterize CCR2+ cells. Autoradiography on a human heart specimen was conducted to confirm binding specificity. 64 Cu- and 68 Ga-DOTA-ECL1i were compared in an ischemia-reperfusion injury mouse model. Results: 64 Cu-DOTA-ECL1i showed sensitive and specific detection of CCR2+ cells in all tested mouse models, with efficacy comparable to that of 68 Ga-DOTA-ECL1i. Flow cytometry demonstrated specific expression of CCR2 on monocytes and macrophages. The tracer binds to human CCR2. Conclusion: This work establishes the utility of 64 Cu-DOTA-ECL1i to image CCR2+ monocytes and macrophages in mouse models and provides the requisite preclinical information to translate the targeted clinical-grade CCR2 imaging probe for clinical investigation of heart diseases. |
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| DOI: | doi:10.2967/jnumed.120.244673 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.2967/jnumed.120.244673 |
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| | Volltext: https://jnm.snmjournals.org/content/62/1/111 |
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| | DOI: https://doi.org/10.2967/jnumed.120.244673 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1760989460 |
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| Verknüpfungen: | → Zeitschrift |
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Targeted PET imaging of chemokine receptor 2-positive monocytes and macrophages in the injured heart / Heo, Gyu Seong [VerfasserIn]; May 22, 2020 (Online-Ressource)
