Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Su, Qin [VerfasserIn]   i
 Benner, Axel [VerfasserIn]   i
 Hofmann, Walter J. [VerfasserIn]   i
 Otto, Gerd [VerfasserIn]   i
 Pichlmayr, Rudolf [VerfasserIn]   i
 Bannasch, Peter [VerfasserIn]   i
Titel:Human hepatic preneoplasia
Titelzusatz:phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia
Verf.angabe:Qin Su, Axel Benner, Walter J. Hofmann, Gerhard Otto, Rudolf Pichlmayr, Peter Bannasch
E-Jahr:1997
Jahr:November 1997
Umfang:16 S.
Teil:volume:431
 year:1997
 number:6
 month:12
 pages:391-406
 extent:16
Fussnoten:Gesehen am 23.06.2021
Titel Quelle:Enthalten in: Virchows Archiv
Ort Quelle:Berlin : Springer, 1847
Jahr Quelle:1997
Band/Heft Quelle:431(1997), 6 vom: Dez., Seite 391-406
ISSN Quelle:1432-2307
Abstract:Foci of altered hepatocytes (FAH) represent preneoplastic lesions, as shown in various animal models of hepatocarcinogenesis, but their significance in the human liver has not been established. The cellular composition, size distribution and proliferation kinetics of FAH in 163 explanted and resected human livers with or without hepatocellular carcinoma (HCC) and their possible association with small-cell change of hepatocytes (SCC) were therefore studied. FAH, including glycogen-storing foci, were found in 84 of 111 cirrhotic livers, demonstrating higher incidences in cases with (29/32) than in those without HCC (55/79). FAH were observed more frequently in HCC-free cirrhosis associated with hepatitis B or C virus or chronic alcoholic abuse (high-risk group) (37/47) than in that due to other causes (low-risk group) (12/21). MCF, predominant in cirrhotic livers of the high-risk group, were more proliferative, larger and more often involved in formation of nodules of altered hepatocytes (39.3%) than were GSF (8.5%). The results suggest that the FAH are preneoplastic lesions, MCF being more advanced than GSF. Oncocytic and amphophilic cell foci were also observed, but their significance remains to be clarified. Two types of SCC, namely diffuse and intrafocal SCC, were identified, but only intrafocal SCC was found to be related to increased proliferative activity and more frequent nodular transformation of the FAH involved, suggesting a close association with progression from FAH to HCC.
DOI:doi:10.1007/s004280050116
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

DOI: https://doi.org/10.1007/s004280050116
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescent
 Adult
 Aged
 Carcinoma, Hepatocellular
 Cell Division
 Child
 Child, Preschool
 Female
 Glycogen
 Hepatitis
 Humans
 Immunohistochemistry
 Infant
 Liver Cirrhosis
 Liver Diseases
 Liver Neoplasms
 Male
 Middle Aged
 Precancerous Conditions
 Proliferating Cell Nuclear Antigen
K10plus-PPN:176111834X
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68751891   QR-Code
zum Seitenanfang