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| Verfasst von: | Martínez, Carmen [VerfasserIn]  |
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| | Canals, C. [VerfasserIn] |
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| | Sarina, B. [VerfasserIn] |
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| | Alessandrino, E. P. [VerfasserIn] |
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| | Karakasis, D. [VerfasserIn] |
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| | Pulsoni, A. [VerfasserIn] |
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| | Sica, S. [VerfasserIn] |
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| | Trneny, M. [VerfasserIn] |
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| | Snowden, J. A. [VerfasserIn] |
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| | Kanfer, E. [VerfasserIn] |
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| | Milpied, N. [VerfasserIn] |
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| | Bosi, A. [VerfasserIn] |
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| | Guidi, S. [VerfasserIn] |
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| | de Souza, C. A. [VerfasserIn] |
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| | Willemze, R. [VerfasserIn] |
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| | Arranz, R. [VerfasserIn] |
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| | Jebavy, L. [VerfasserIn] |
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| | Hellmann, A. [VerfasserIn] |
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| | Sibon, D. [VerfasserIn] |
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| | Oneto, R. [VerfasserIn] |
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| | Luan, J. J. [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Castagna, L. [VerfasserIn] |
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| | Sureda, A. [VerfasserIn] |
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| Titel: | Identification of prognostic factors predicting outcome in Hodgkin's lymphoma patients relapsing after autologous stem cell transplantation† |
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| Verf.angabe: | C. Martínez, C. Canals, B. Sarina, E.P. Alessandrino, D. Karakasis, A. Pulsoni, S. Sica, M. Trneny, J.A. Snowden, E. Kanfer, N. Milpied, A. Bosi, S. Guidi, C.A. de Souza, R. Willemze, R. Arranz, L. Jebavy, A. Hellmann, D. Sibon, R. Oneto, J.J. Luan, P. Dreger, L. Castagna, & A. Sureda, for the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (EBMT) and the Gruppo Italiano Trapianto di MidolloOsseo(GITMO) |
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| E-Jahr: | 2013 |
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| Jahr: | 26 May 2013 |
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| Umfang: | 5 S. |
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| Teil: | volume:24 |
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| | year:2013 |
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| | number:9 |
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| | month:09 |
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| | pages:2430-2434 |
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| | extent:5 |
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| Fussnoten: | Gesehen am 23.06.2021 |
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| Titel Quelle: | Enthalten in: Annals of oncology |
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| Ort Quelle: | Amsterdam [u.a. : Elsevier, 1990 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 24(2013), 9 vom: Sept., Seite 2430-2434 |
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| ISSN Quelle: | 1569-8041 |
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| Abstract: | Background - High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard of care for patients with relapsed Hodgkin's lymphoma (HL). However, there is currently little information on the predictors of outcome for patients whose disease recurs after ASCT. - Methods - Five hundred and eleven adult patients with relapsed HL after ASCT from EBMT-GITMO databases were reviewed. - Results - Treatments administered following ASCT failure included conventional chemotherapy and/or radiotherapy in 294 (64%) patients, second ASCT in 35 (8%), and alloSCT in 133 (29%). After a median follow-up of 49 months, overall survival (OS) was 32% at 5 years. Independent risk factors for OS were early relapse (<6 months) after ASCT, stage IV, bulky disease, poor performance status (PS), and age ≥50 years at relapse. For patients with no risk factors OS at 5 years was 62% compared with 37% and 12% for those having 1 and ≥2 factors, respectively. This score was also predictive for outcome in each group of rescue treatment after ASCT failure. - Conclusion(s) - Early relapse, stage IV, bulky disease, poor PS, and age ≥50 years at ASCT failure are relevant factors for outcome that may help to understand the results of different therapeutic approaches. |
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| DOI: | doi:10.1093/annonc/mdt206 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1093/annonc/mdt206 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0923753419369443 |
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| | DOI: https://doi.org/10.1093/annonc/mdt206 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | autologous stem cell transplantation |
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| | Hodgkin's lymphoma |
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| | relapse |
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| K10plus-PPN: | 1761140663 |
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| Verknüpfungen: | → Zeitschrift |
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Identification of prognostic factors predicting outcome in Hodgkin's lymphoma patients relapsing after autologous stem cell transplantation† / Martínez, Carmen [VerfasserIn]; 26 May 2013 (Online-Ressource)
