Coagulation, anticoagulation and pancreatic carcinoma

• Verfasst von: Nakchbandi, Inaam [VerfasserIn]
• Verfasst von: Löhr, J.-Matthias [VerfasserIn]
• Titel: Coagulation, anticoagulation and pancreatic carcinoma
• Verf.angabe: Inaam A. Nakchbandi and J.-Matthias Löhr
• E-Jahr: 2008
• Jahr: 1 July 2008
• Umfang: 11 S.
• Fussnoten: Gesehen am 28.06.2021
• Titel Quelle: Enthalten in: Nature Clinical Practice / Gastroenterology & Hepatology
• Ort Quelle: Basingstoke : Nature Publishing Group, 2004
• Jahr Quelle: 2008
• Band/Heft Quelle: 5(2008), 8, Seite 445-455
• ISSN Quelle: 1743-4386
• DOI: doi:10.1038/ncpgasthep1184
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Anticoagulants
• Sach-SW: Blood Coagulation
• Sach-SW: Heparin
• Sach-SW: Humans
• Sach-SW: Pancreatic Neoplasms
• Sach-SW: Recurrence
• Sach-SW: Thromboembolism
• Sach-SW: Warfarin
• K10plus-PPN: 1761363409

Abstract

An increase in coagulation in patients with pancreatic carcinoma has long been documented. In this Review, we present what is known about the pathophysiology of increased coagulation in cancer and how it applies to pancreatic carcinoma. The relationship between the activation of coagulation or symptomatic thromboembolic disease and the development of pancreatic carcinoma is explored. Data on the relationship between thromboembolic disease and the behavior of pancreatic cancer before, during or after a diagnosis is made are also reviewed. Finally, the rationale and evidence for the use of oral anticoagulants or heparin in patients with pancreatic carcinoma is presented. This Review is a critical appraisal of what is known, and when the evidence is acceptable, on the subject of thromboembolism, anticoagulation, and treatment with anticoagulants in patients with pancreatic carcinoma.