| |  Online-Ressource |
|---|
| Verfasst von: | Schmidt, Sarah [VerfasserIn]  |
|---|
| | Nakchbandi, Inaam [VerfasserIn] |
|---|
| | Ruppert, Raphael [VerfasserIn] |
|---|
| | Kawelke, Nina [VerfasserIn] |
|---|
| | Hess, Michael W. [VerfasserIn] |
|---|
| | Pfaller, Kristian [VerfasserIn] |
|---|
| | Jurdic, Pierre [VerfasserIn] |
|---|
| | Fässler, Reinhard [VerfasserIn] |
|---|
| | Moser, Markus [VerfasserIn] |
|---|
| Titel: | Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption |
|---|
| Verf.angabe: | Sarah Schmidt, Inaam Nakchbandi, Raphael Ruppert, Nina Kawelke, Michael W. Hess, Kristian Pfaller, Pierre Jurdic, Reinhard Fässler, and Markus Moser |
|---|
| Jahr: | 2011 |
|---|
| Umfang: | 15 S. |
|---|
| Fussnoten: | Gesehen am 28.06.2021 |
|---|
| Titel Quelle: | Enthalten in: The journal of cell biology |
|---|
| Ort Quelle: | New York, NY : Rockefeller Univ. Press, 1962 |
|---|
| Jahr Quelle: | 2011 |
|---|
| Band/Heft Quelle: | 192(2011), 5, Seite 883-897 |
|---|
| ISSN Quelle: | 1540-8140 |
|---|
| Abstract: | The blood cell-specific kindlin-3 protein is required to activate leukocyte and platelet integrins. In line with this function, mutations in the KINDLIN-3 gene in man cause immunodeficiency and severe bleeding. Some patients also suffer from osteopetrosis, but the underlying mechanism leading to abnormal bone turnover is unknown. Here we show that kindlin-3-deficient mice develop severe osteopetrosis because of profound adhesion and spreading defects in bone-resorbing osteoclasts. Mechanistically, loss of kindlin-3 impairs the activation of β1, β2, and β3 integrin classes expressed on osteoclasts, which in turn abrogates the formation of podosomes and sealing zones required for bone resorption. In agreement with these findings, genetic ablation of all integrin classes abolishes the development of podosomes, mimicking kindlin-3 deficiency. Although loss of single integrin classes gives rise to podosomes, their resorptive activity is impaired. These findings show that osteoclasts require their entire integrin repertoire to be regulated by kindlin-3 to orchestrate bone homeostasis. |
|---|
| DOI: | doi:10.1083/jcb.201007141 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/ 10.1083/jcb.201007141 |
|---|
| | Volltext: https://rupress.org/jcb/article/192/5/883/36392/Kindlin-3-mediated-signaling-from-multiple |
|---|
| | DOI: https://doi.org/10.1083/jcb.201007141 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Animals |
|---|
| | Bone Resorption |
|---|
| | CD18 Antigens |
|---|
| | Cell Differentiation |
|---|
| | Cytoskeletal Proteins |
|---|
| | Integrin beta1 |
|---|
| | Integrin beta3 |
|---|
| | Intercellular Signaling Peptides and Proteins |
|---|
| | Mice |
|---|
| | Osteoclasts |
|---|
| | Osteopetrosis |
|---|
| | Signal Transduction |
|---|
| K10plus-PPN: | 1761374362 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption / Schmidt, Sarah [VerfasserIn]; 2011 (Online-Ressource)
