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Verfasst von:Küntzelmann, Anika [VerfasserIn]   i
 Guenther, Thomas [VerfasserIn]   i
 Haberkorn, Uwe [VerfasserIn]   i
 Essig, Marco [VerfasserIn]   i
 Giesel, Frederik L. [VerfasserIn]   i
 Henze, Romy [VerfasserIn]   i
 Schroeter, Matthias L. [VerfasserIn]   i
 Schröder, Johannes [VerfasserIn]   i
 Schönknecht, Peter [VerfasserIn]   i
Titel:Impaired cerebral glucose metabolism in prodromal Alzheimer's disease differs by regional intensity normalization
Verf.angabe:Anika Küntzelmann, Thomas Guenther, Uwe Haberkorn, Marco Essig, Frederik Giesel, Romy Henze, Matthias L. Schroeter, Johannes Schröder, Peter Schönknecht
Jahr:2013
Umfang:6 S.
Teil:volume:534
 year:2013
 month:02
 pages:12-17
 extent:6
Fussnoten:Available online 23 November 2012 ; Gesehen am 28.06.2021
Titel Quelle:Enthalten in: Neuroscience letters
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2013
Band/Heft Quelle:534(2013) vom: Feb., Seite 12-17
ISSN Quelle:1872-7972
Abstract:Using [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET) patients with Alzheimer's disease show impairment of cerebral glucose metabolism in bilateral frontotemporoparietal association cortices and posterior cingulate cortex whereas in patients with mild cognitive impairment (MCI) results are heterogeneous. For the first time, the present study examined alterations of the cerebral glucose metabolism in patients with prodromal AD as compared to patients with AD dementia and healthy controls depending on intensity normalization. 15 patients with AD (69.8±8.5 years) and 28 with prodromal AD (67.4±9.1 years) as well as 10 healthy controls (58.8±5.9 years) underwent FDG PET under resting conditions. By statistical parametric mapping 8, analyses were performed using (a) cerebellar cortex or (b) whole brain as reference region for intensity normalization. Patients with AD dementia showed reductions in bilateral temporoparietal regions and posterior cingulate gyrus as compared to controls. By contrast, patients with prodromal AD had only reductions in the left posterior temporal lobe and left angular gyrus as compared with controls. Cerebellar normalization was superior in differentiating patients with prodromal AD or AD dementia from healthy controls, but global normalization provided slightly better contrasts for the differentiation between patients with prodromal AD and AD dementia in AD-typical regions. Unexpected hypermetabolism in patients was only revealed using global normalization and has to be regarded as an artifact of intensity normalization to a reference region affected by the disease.
DOI:doi:10.1016/j.neulet.2012.11.026
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.neulet.2012.11.026
 Volltext: https://www.sciencedirect.com/science/article/pii/S0304394012014838
 DOI: https://doi.org/10.1016/j.neulet.2012.11.026
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Alzheimer's disease dementia
 FDG PET
 Intensity normalization
 Prodromal Alzheimer's disease
K10plus-PPN:1761374613
Verknüpfungen:→ Zeitschrift

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